Aging and animal models of systemic insult: Trauma, burn, and sepsis

Vanessa Nomellini, Christian R. Gomez, Richard L. Gamelli, Elizabeth J. Kovacs

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


In the acute-care setting, it is widely accepted that elderly patients have increased morbidity and mortality compared with young healthy patients. The reasons for this, however, are largely unknown. Although animal modeling has helped improve treatment strategies for young patients, there are a scarce number of studies attempting to understand the mechanisms of systemic insults such as trauma, burn, and sepsis in aged individuals. This review aims to highlight the relevance of using animals to study the pathogenesis of these insults in the aged and, despite the deficiency of information, to summarize what is currently known in this field.

Original languageEnglish (US)
Pages (from-to)11-20
Number of pages10
Issue number1
StatePublished - Jan 2009
Externally publishedYes


  • Blunt trauma
  • Burn injury
  • Elderly
  • Hemorrhage
  • Penetrating trauma
  • Sepsis
  • Traumatic brain injury

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine


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