Age-related decline in circadian output

Takahiro J. Nakamura, Wataru Nakamura, Shin Yamazaki, Takashi Kudo, Tamara Cutler, Christopher S. Colwell, Gene D. Block

Research output: Contribution to journalArticlepeer-review

278 Scopus citations


Disruptions in sleep/wake cycles, including decreased amplitude of rhythmic behaviors and fragmentation of the sleep episodes, are commonly associated with aging in humans and other mammals. While there are undoubtedly many factors contributing to these changes, a body of literature is emerging, suggesting that an age-related decline in the central circadian clock in the suprachiasmatic nucleus (SCN) may be a key element responsible. Toexplore age-related changes in the SCN, wehave performed in vivo multiunit neural activity(MUA)recordings from the SCN of freely moving young (3-5 months) and middle-aged (13-18 months) mice. Importantly, the amplitude of day-night difference in MUA was significantly reduced in the older mice. Wealso found that the neural activity rhythms are clearly degraded in the sub paraventricular zone, one of the main neural outputs of the SCN. Surprisingly, parallel studies indicate that the molecular clockwork in the SCN as measured by PER2 exhibited only minor deficits at this same age. Thus, the circadian output measured at the level of neural activity rhythms in the SCN is degraded by aging, and this decline occurs before the disruption of key components of the molecular clockwork.

Original languageEnglish (US)
Pages (from-to)10201-10205
Number of pages5
JournalJournal of Neuroscience
Issue number28
StatePublished - Jul 13 2011

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Age-related decline in circadian output'. Together they form a unique fingerprint.

Cite this