Age-dependent prognostic value of KRAS mutation in metastatic colorectal cancer

Muhammet Ozer, Suleyman Yasin Goksu, Nina Niu Sanford, Chul Ahn, Muhammad Shaalan Beg, Syed Mohammad Ali Kazmi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: The age-dependent prognostic impact of KRAS status in metastatic colorectal cancer (mCRC) is unknown. Materials & Methods: We used the National Cancer Database to evaluate the survival by KRAS status for age-groups <50, 50-69 and ≥70, adjusting for relevant patient and tumor characteristics. Results: mCRC patients (n = 26,095; 33.5%) had KRAS status reported, and 11,338 of these patients (43.4%) had mutations in the KRAS gene. Patients with KRAS mutations had worse overall survival than wild-type KRAS patients. In age-groups <50 years (23 vs 29 months; p < 0.001) and 50-69 (21 vs 23.4 months; p < 0.001), KRAS mutations were significantly associated with worse survival, whereas in the ≥70-year age-group, there was no significant association (14 vs 14 months; p = 0.34). Conclusion: We conclude that the age of patients influences the prognostic value of KRAS mutation in metastatic colorectal cancer.

Original languageEnglish (US)
Pages (from-to)4883-4893
Number of pages11
JournalFuture Oncology
Issue number35
StatePublished - Dec 2021


  • KRAS
  • age of onset
  • colorectal neoplasms
  • database
  • metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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