Age- and sex-related differences in the tissue Doppler imaging parameters of left ventricular diastolic dysfunction

Hyeun S. Park, Sanjay D. Naik, Wilbert S. Aronow, Chul W. Ahn, John A. McClung, Robert N. Belkin

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background: The effect of age and gender on tissue Doppler imaging measurements comparing the septal and mitral annulus needs to be investigated. Methods: We investigated in 276 outpatients in a university cardiology practice the relationship of age and gender to left atrial (LA) size, LA volume, mitral pulse-wave Doppler E/A ratio, E/Ea ratios by tissue Doppler image of mitral annular velocity (TDI), and left ventricular diastolic dysfunction (LVDD) by TDI. Results: Mitral E/A inflow was statistically decreased with age. E/Ea ratios of the lateral and mean of both lateral and septal annulus showed a statistical increase with age, while the E/Ea ratio of the septal annulus did not correlate with age. When comparing men and women of all ages, the mean LA volume for men was 59.2 cm3 ± 24.36 cm3 versus 48.54 cm3 ± 16.14 cm3 (P-value < 0.0001) and the mean LA size was 4.0 + 0.51 cm for men and 3.65 + 0.47 for women (P-value < 0.0001). There was no statistical difference between men and women when looking at mitral E/A inflow ratio, deceleration time, E/Ea ratio of the septal annulus, E/Ea ratio of the lateral annulus, E/Ea ratio of the mean of both septal and lateral annulus, and grades of LVDD. Conclusion: In patients 70 years of age or older, the mean diastolic grade was mild-to-moderate LVDD when using lateral or mean of septal and lateral annular measurements. When only the septal annular measurements were used to determine diastolic grade, all four age groups showed a mean of mildly to moderately impaired LVDD and showed no correlation with age. There were no differences in tissue Doppler imaging measurements between men and women.

Original languageEnglish (US)
Pages (from-to)567-571
Number of pages5
Issue number6
StatePublished - Jul 2007


  • Lateral mitral annulus
  • Left atrial size
  • Left ventricular diastolic dysfunction
  • Septal mitral annulus
  • Tissue Doppler imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Age- and sex-related differences in the tissue Doppler imaging parameters of left ventricular diastolic dysfunction'. Together they form a unique fingerprint.

Cite this