Age and cortisol suppression by dexamethasone in normal subjects

Myron F. Weiner

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


A study of 60 healthy volunteers ranging from 19-88 yr of age found nonsuppression rare (5%) and confirmed that the dexamethasone suppression test (DST) of the reactivity of the hypophyseal-pituitary-adrenal axis to negative feedback inhibition requires 0800 h plasma dexamethasone (DEX) levels in excess of 220 ng/dl. All of the subjects with inadequate DEX levels (N=3) were older than 50 yr of age as were the nonsuppressors (N=3); two of the three nonsuppressors had inadequate DEX concentrations. Thus, DST may be more often invalid in elders than in younger adults because of inadequate plasma dexamethasone (DEX) concentration, indicating that plasma DEX levels should be assayed concomitantly with DST in elders.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalJournal of Psychiatric Research
Issue number2
StatePublished - 1989

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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