Advances in Revascularization for Peripheral Artery Disease: Revascularization in PAD

Joshua A. Beckman, Peter A. Schneider, Michael S. Conte

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Effective revascularization of the patient with peripheral artery disease is about more than the procedure. The approach to the patient with symptom-limiting intermittent claudication or limb-threatening ischemia begins with understanding the population at risk and variation in clinical presentation. The urgency of revascularization varies significantly by presentation; from patients with intermittent claudication who should undergo structured exercise rehabilitation before revascularization (if needed) to those with acute limb ischemia, a medical emergency, who require revascularization within hours. Recent years have seen the rapid development of new tools including wires, catheters, drug-eluting technology, specialized balloons, and biomimetic stents. Open surgical bypass remains an important option for those with advanced disease. The strategy and techniques employed vary by clinical presentation, lesion location, and lesion severity. There is limited level 1 evidence to guide practice, but factors that determine technical success and anatomic durability are largely understood and incorporated into decision-making. Following revascularization, medical therapy to reduce adverse limb outcomes and a surveillance plan should be put in place. There are many hurdles to overcome to improve the efficacy of lower extremity revascularization, such as restenosis, calcification, microvascular disease, silent embolization, and tools for perfusion assessment. This review highlights the current state of revascularization in peripheral artery disease with an eye toward technologies at the cusp, which may significantly impact current practice.

Original languageEnglish (US)
Pages (from-to)1885-1912
Number of pages28
JournalCirculation research
Issue number12
StatePublished - Jun 11 2021
Externally publishedYes


  • catheter
  • decision-making
  • intermittent claudication
  • peripheral arterial disease
  • risk factor

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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