TY - JOUR
T1 - Advances in prostate cancer research models
T2 - From transgenic mice to tumor xenografting models
AU - Huang, Yuejiao
AU - Cheng, Chun
AU - Zhang, Chong
AU - Zhang, Yonghui
AU - Chen, Miaomiao
AU - Strand, Douglas W.
AU - Jiang, Ming
N1 - Publisher Copyright:
© 2016 Editorial Office of Asian Journal of Urology.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - The identification of the origin and molecular characteristics of prostate cancer (PCa) has crucial implications for personalized treatment. The development of effective treatments for PCa has been limited; however, the recent establishment of several transgenic mouse lines and/or xenografting models is better reflecting the disease in vivo. With appropriate models, valuable tools for elucidating the functions of specific genes have gone deep into prostate development and carcinogenesis. In the present review, we summarize a number of important PCa research models established in our laboratories (PSA-Cre-ERT2/PTEN transgenic mouse models, AP-OX model, tissue recombination-xenografting models and PDX models), which represent advances of translational models from transgenic mouse lines to human tumor xenografting. Better understanding of the developments of these models will offer new insights into tumor progression and may help explain the functional significance of genetic variations in PCa. Additionally, this understanding could lead to new modes for curing PCa based on their particular biological phenotypes.
AB - The identification of the origin and molecular characteristics of prostate cancer (PCa) has crucial implications for personalized treatment. The development of effective treatments for PCa has been limited; however, the recent establishment of several transgenic mouse lines and/or xenografting models is better reflecting the disease in vivo. With appropriate models, valuable tools for elucidating the functions of specific genes have gone deep into prostate development and carcinogenesis. In the present review, we summarize a number of important PCa research models established in our laboratories (PSA-Cre-ERT2/PTEN transgenic mouse models, AP-OX model, tissue recombination-xenografting models and PDX models), which represent advances of translational models from transgenic mouse lines to human tumor xenografting. Better understanding of the developments of these models will offer new insights into tumor progression and may help explain the functional significance of genetic variations in PCa. Additionally, this understanding could lead to new modes for curing PCa based on their particular biological phenotypes.
KW - Prostate cancer
KW - Transgenic mouse lines
KW - Translational medical systems
KW - Tumor xenografting models
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U2 - 10.1016/j.ajur.2016.02.004
DO - 10.1016/j.ajur.2016.02.004
M3 - Review article
C2 - 29264167
AN - SCOPUS:85027891089
SN - 2214-3882
VL - 3
SP - 64
EP - 74
JO - Asian Journal of Urology
JF - Asian Journal of Urology
IS - 2
ER -