The endogenous neuromodulatory purine, adenosine, substantially attenuated neuronal degeneration when added to dissociated cortical cell cultures acutely deprived of either oxygen or glucose. The protective effect of adenosine was concentration-dependent between 30 and 1000 μM (EC50 about 100 μM), and could be mimicked by the stable adenosine analogue N6-cyclohexyladenosine (10 μM). Unlike postsynaptic glutamate receptor antagonists, which also block these forms of neuronal injury, adenosine did not alter the neurotoxicity of exogenously applied glutamate.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Jul 8 1988|
- Cell culture
- Cerebral cortex
ASJC Scopus subject areas