Adenosine enhances afterhyperpolarization and accommodation in hippocampal pyramidal cells

Helmut L. Haas, Robert W. Greene

Research output: Contribution to journalArticlepeer-review

101 Scopus citations


Adenosine added to the perfusion fluid of rat hippocampal slices at 10 μmol · l-1 enhanced long lasting afterhyperpolarizations after single action potentials, bursts of action potentials or calcium spikes. Accommodation of firing during a depolarizing pulse was potentiated. An increase in calcium dependent potassium conductance is likely to mediate these effects. Adenosine at 50 μmol·l-1 induced a hyperpolarization accompanied by a reduction in input resistance. The hyperpolarization could be reversed at -85 mV. In TTX and TTX-barium treated slices the amplitude of the slow spike was decreased. This may result from a shunting of inward current in the dendrites due to an adenosine induced increase in potassium conductance. It is suggested that adenosine reduces pre- and postsynaptic exicatory signals principally by enhancing one or more potassium conductances. This effect is a powerful means for modulation of neuronal excitability and synaptic efficacy and can explain the antiepileptic activity of adenosine.

Original languageEnglish (US)
Pages (from-to)244-247
Number of pages4
JournalPflügers Archiv European Journal of Physiology
Issue number3
StatePublished - Nov 1984


  • Accommodation
  • Adenosine
  • Afterhyperpolarization
  • Calcium
  • Hippocampal slice
  • Potassium

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)


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