Addressing the challenges of phenotyping pediatric pulmonary vascular disease

Kara N. Goss; Allen D. Everett; Peter M. Mourani; Christopher D. Baker; Steven H. Abman

doi:10.1086/689750

Addressing the challenges of phenotyping pediatric pulmonary vascular disease

Kara N. Goss, Allen D. Everett, Peter M. Mourani, Christopher D. Baker, Steven H. Abman

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Pediatric pulmonary vascular disease (PVD) and pulmonary hypertension (PH) represent phenotypically and pathophysiologically diverse disease categories, contributing substantial morbidity and mortality to a complex array of pediatric conditions. Here, we review the multifactorial nature of pediatric PVD, with an emphasis on improved recognition, phenotyping, and endotyping strategies for pediatric PH. Novel tailored approaches to diagnosis and treatment in pediatric PVD, as well as the implications for long-term outcomes, are highlighted.

Original language	English (US)
Pages (from-to)	7-19
Number of pages	13
Journal	Pulmonary Circulation
Volume	7
Issue number	1
DOIs	https://doi.org/10.1086/689750
State	Published - 2017
Externally published	Yes

Keywords

Childhood
Long-term outcomes
Pulmonary hypertension
Registry studies

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1086/689750

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title = "Addressing the challenges of phenotyping pediatric pulmonary vascular disease",

abstract = "Pediatric pulmonary vascular disease (PVD) and pulmonary hypertension (PH) represent phenotypically and pathophysiologically diverse disease categories, contributing substantial morbidity and mortality to a complex array of pediatric conditions. Here, we review the multifactorial nature of pediatric PVD, with an emphasis on improved recognition, phenotyping, and endotyping strategies for pediatric PH. Novel tailored approaches to diagnosis and treatment in pediatric PVD, as well as the implications for long-term outcomes, are highlighted.",

keywords = "Childhood, Long-term outcomes, Pulmonary hypertension, Registry studies",

author = "Goss, {Kara N.} and Everett, {Allen D.} and Mourani, {Peter M.} and Baker, {Christopher D.} and Abman, {Steven H.}",

note = "Funding Information: This work was supported in part by NHLBI U01 HL12118-01 (SHA) and NHLBI RO1 HL085703 (SHA). Publisher Copyright: {\textcopyright} 2017 by Pulmonary Vascular Research Institute.",

year = "2017",

doi = "10.1086/689750",

language = "English (US)",

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journal = "Pulmonary Circulation",

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T1 - Addressing the challenges of phenotyping pediatric pulmonary vascular disease

AU - Goss, Kara N.

AU - Everett, Allen D.

AU - Mourani, Peter M.

AU - Baker, Christopher D.

AU - Abman, Steven H.

PY - 2017

Y1 - 2017

N2 - Pediatric pulmonary vascular disease (PVD) and pulmonary hypertension (PH) represent phenotypically and pathophysiologically diverse disease categories, contributing substantial morbidity and mortality to a complex array of pediatric conditions. Here, we review the multifactorial nature of pediatric PVD, with an emphasis on improved recognition, phenotyping, and endotyping strategies for pediatric PH. Novel tailored approaches to diagnosis and treatment in pediatric PVD, as well as the implications for long-term outcomes, are highlighted.

AB - Pediatric pulmonary vascular disease (PVD) and pulmonary hypertension (PH) represent phenotypically and pathophysiologically diverse disease categories, contributing substantial morbidity and mortality to a complex array of pediatric conditions. Here, we review the multifactorial nature of pediatric PVD, with an emphasis on improved recognition, phenotyping, and endotyping strategies for pediatric PH. Novel tailored approaches to diagnosis and treatment in pediatric PVD, as well as the implications for long-term outcomes, are highlighted.

KW - Childhood

KW - Long-term outcomes

KW - Pulmonary hypertension

KW - Registry studies

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JO - Pulmonary Circulation

JF - Pulmonary Circulation

IS - 1

ER -

Addressing the challenges of phenotyping pediatric pulmonary vascular disease

Abstract

Keywords

ASJC Scopus subject areas

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