@inproceedings{2d30f4175bf542259488f0d88fa89eec,
title = "Adaptive thermal therapy using planar ultrasound transducers with real-time MR temperature feedback: Demonstration in gel phantoms and ex-vivo tissues",
abstract = "MRI-guided transurethral ultrasound therapy offers a minimally invasive approach for the treatment of localized prostate cancer. The main goal of this study was to evaluate active temperature feedback on a clinical 1.5T MR imager to control conformal thermal therapy. MR thermometry was performed during heating in both thermal gel phantoms and ex-vivo tissue with a single-element transurethral heating applicator. The applicator rotation rate and power were controlled based on MRI-temperature measurements. The influence of a cooling gradient (to simulate cooling of the rectum or urethra) was also investigated in gel phantoms. The 55°C isotherm generated during heating closely matched the targeted prostate shape, with an average distance error of 0.9 mm ± 0.4 mm in turkey breasts, 1.3 mm ± 0.5 mm in gel phantoms without rectal cooling and 1.4 mm ± 0.6 mm in gel phantoms with rectal cooling. Accurate, MRI-guided, active feedback has been successfully demonstrated experimentally and has the capability to adjust for unpredictable and varying tissue properties during the treatment.",
keywords = "Active feedback, MRI-guided, Prostate, Thermal therapy, Transurethral",
author = "Kee Tang and Vanessa Choy and Rajiv Chopra and Michael Bronskill",
year = "2007",
month = sep,
day = "24",
doi = "10.1063/1.2744289",
language = "English (US)",
isbn = "0735404194",
series = "AIP Conference Proceedings",
pages = "300--306",
booktitle = "6th International Symposium on Therapeutic Ultrasound",
note = "6TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND ; Conference date: 30-08-2007 Through 02-09-2007",
}