Adamantinoma-like Ewing sarcoma of the parotid gland: Cytopathologic findings and differential diagnosis

Mohammed T. Lilo, Justin A. Bishop, Matthew T. Olson, Syed Z. Ali

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Adamantinoma-like Ewing sarcoma (AES) is a rare variant of Ewing sarcoma family of tumors (EFTs), primarily affecting bone and soft tissue. AES has mixed features of Ewing sarcoma (ES)/primitive neuroectodermal tumor (PNET) and adamantinoma with a complex immunoprofile and EWSR1 gene rearrangements. Herein, we report a 72-year-old male who presented with left parotid mass, right neck mass and thyroid nodules. Fine needle aspiration of the left parotid mass displayed nests of monotonous epithelioid cells with basaloid features in a background of small round blue cells and lymphocytes. AES can involve head and neck region and is characterized by groups of primitive small round blue cells admixed with groups of epithelioid cells with amphophilic cytoplasm and focal squamous differentiation. The proportion of these components can be variable, creating diagnostic challenges, particularly in unusual anatomic sites such as the parotid gland. However, when additional material is available, CD99 and/or FLI1 immunostains need to be included for diagnostic confirmation.

Original languageEnglish (US)
JournalDiagnostic Cytopathology
StateAccepted/In press - Jan 1 2017


  • Adamantinoma-like
  • Cytopathology
  • Ewing sarcoma
  • Fine needle aspiration
  • Parotid
  • Salivary gland

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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