Acute silent cerebral infarction in children with sickle cell anemia

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45 Scopus citations


Silent cerebral infarctions (SCI) occur in up to 35% of children with sickle cell anemia (HbSS) but are rarely recognized during the initial 10-14 days when diffusion weighted magnetic resonance imaging (MRI) can differentiate acute infarctions from remote events. We report acute SCI in seven children with HbSS who had areas of restricted diffusion on MRI without persistent focal neurologic deficits. Four had acute SCI identified following acute anemic events. Our observations suggest that SCI are detectible in the acute phase, present with subtle neurologic symptoms, result in permanent neurologic injury, and may be caused by acute anemic events.

Original languageEnglish (US)
Pages (from-to)461-464
Number of pages4
JournalPediatric Blood and Cancer
Issue number3
StatePublished - Mar 2010


  • Anemia
  • Neurology and sickle cell
  • Parvovirus B19 with sickle cell anemia
  • Sickle cell disease
  • Stroke

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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