Acute myocardial infarction imaged with 99Tc(m) stannous pyrophosphate and 201Tl: A clinical evaluation

R. W. Parkey, F. J. Bonte, E. M. Stokely, S. E. Lewis, K. D. Graham, L. M. Buja, J. T. Willerson

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22 Scopus citations


Twenty six patients suspected of having acute myocardial infarction (AMI) underwent myocardial scintigraphy sequentially with 201Tl and 99(m)Tc stannous pyrophosphate ( 99(m)Tc PP(i)). Of the 26 patients, 24 had AMI documented by enzyme and electrocardiographic changes. Nineteen had transmural and five had subendocardial myocardial infarctions. The remaining two patients had 'unstable angina pectoris'. The mean time from onset to imaging was 4 days. Of the 24 patients with AMI, 22 had positive 99(m)Tc PP(i) scintigrams. In 20 the area of acute myocardial damage appeared to be the same by 99(m)Tc PP(i) scintigram as by ECG; in two, the location could not be precisely determined. The two patients with negative 99(m)Tc PP(i) scintigrams at the time of combined myocardial imaging had had positive 99(m)Tc PP(i) images previously. In all 24 patients, the 201Tl images were abnormal in at least the location suggested by the electrocardiogram. In seven patients, the area of decreased 201Tl activity was grossly equal to the positive area on the 99(m)Tc PP(i) images; in 15, the 201Tl defect was definitely larger; and in two, the 201Tl defect appeared slightly smaller. Although the 99(m)Tc PP(i) and 201Tl myocardial images provide different information, both are valuable in determining the overall integrity of the myocardium in patients with ischemic heart disease.

Original languageEnglish (US)
Pages (from-to)771-779
Number of pages9
JournalJournal of Nuclear Medicine
Issue number9
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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