Acute Myeloid Leukemia With Myelodysplasia-Related Changes: A New Definition

Olga K. Weinberg, Daniel A. Arber

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Acute myeloid leukemia (AML) with multilineage dysplasia was introduced in the 2001 World Health Organization (WHO) classification to encompass cases of AML characterized by myelodysplastic syndrome-like features. The 2008 WHO classification revised this group into a new category, AML with myelodysplasia-related changes (AML-MRC). The category now includes patients with at least 20% blasts in peripheral blood or bone marrow and any of the following: (1) AML arising from a previous MDS or mixed MDS/myeloproliferative neoplasm, (2) AML with a specific MDS-associated cytogenetic abnormality and/or (3) AML with multilineage dysplasia. Up to 48% of all patients with AML are encompassed within the AML-MRC subgroup. AML-MRC patients have worse prognosis compared with patients with AML, not otherwise specified.

Original languageEnglish (US)
Pages (from-to)1153-1164
Number of pages12
JournalSurgical Pathology Clinics
Issue number4
StatePublished - Dec 2010
Externally publishedYes


  • 2008 WHO classification
  • Acute myeloid leukemia
  • Multilineage dysplasia
  • Myelodysplasia-related changes

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine


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