Acute Myeloid Leukemia With Myelodysplasia-Related Changes: A New Definition

Olga K. Weinberg; Daniel A. Arber

doi:10.1016/j.path.2010.09.012

Acute Myeloid Leukemia With Myelodysplasia-Related Changes: A New Definition

Olga K. Weinberg, Daniel A. Arber

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Acute myeloid leukemia (AML) with multilineage dysplasia was introduced in the 2001 World Health Organization (WHO) classification to encompass cases of AML characterized by myelodysplastic syndrome-like features. The 2008 WHO classification revised this group into a new category, AML with myelodysplasia-related changes (AML-MRC). The category now includes patients with at least 20% blasts in peripheral blood or bone marrow and any of the following: (1) AML arising from a previous MDS or mixed MDS/myeloproliferative neoplasm, (2) AML with a specific MDS-associated cytogenetic abnormality and/or (3) AML with multilineage dysplasia. Up to 48% of all patients with AML are encompassed within the AML-MRC subgroup. AML-MRC patients have worse prognosis compared with patients with AML, not otherwise specified.

Original language	English (US)
Pages (from-to)	1153-1164
Number of pages	12
Journal	Surgical Pathology Clinics
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/j.path.2010.09.012
State	Published - Dec 2010
Externally published	Yes

Keywords

2008 WHO classification
Acute myeloid leukemia
Multilineage dysplasia
Myelodysplasia-related changes

ASJC Scopus subject areas

Surgery
Pathology and Forensic Medicine

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10.1016/j.path.2010.09.012

Cite this

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title = "Acute Myeloid Leukemia With Myelodysplasia-Related Changes: A New Definition",

abstract = "Acute myeloid leukemia (AML) with multilineage dysplasia was introduced in the 2001 World Health Organization (WHO) classification to encompass cases of AML characterized by myelodysplastic syndrome-like features. The 2008 WHO classification revised this group into a new category, AML with myelodysplasia-related changes (AML-MRC). The category now includes patients with at least 20% blasts in peripheral blood or bone marrow and any of the following: (1) AML arising from a previous MDS or mixed MDS/myeloproliferative neoplasm, (2) AML with a specific MDS-associated cytogenetic abnormality and/or (3) AML with multilineage dysplasia. Up to 48% of all patients with AML are encompassed within the AML-MRC subgroup. AML-MRC patients have worse prognosis compared with patients with AML, not otherwise specified.",

keywords = "2008 WHO classification, Acute myeloid leukemia, Multilineage dysplasia, Myelodysplasia-related changes",

author = "Weinberg, {Olga K.} and Arber, {Daniel A.}",

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journal = "Surgical Pathology Clinics",

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T1 - Acute Myeloid Leukemia With Myelodysplasia-Related Changes

T2 - A New Definition

AU - Weinberg, Olga K.

AU - Arber, Daniel A.

PY - 2010/12

Y1 - 2010/12

N2 - Acute myeloid leukemia (AML) with multilineage dysplasia was introduced in the 2001 World Health Organization (WHO) classification to encompass cases of AML characterized by myelodysplastic syndrome-like features. The 2008 WHO classification revised this group into a new category, AML with myelodysplasia-related changes (AML-MRC). The category now includes patients with at least 20% blasts in peripheral blood or bone marrow and any of the following: (1) AML arising from a previous MDS or mixed MDS/myeloproliferative neoplasm, (2) AML with a specific MDS-associated cytogenetic abnormality and/or (3) AML with multilineage dysplasia. Up to 48% of all patients with AML are encompassed within the AML-MRC subgroup. AML-MRC patients have worse prognosis compared with patients with AML, not otherwise specified.

AB - Acute myeloid leukemia (AML) with multilineage dysplasia was introduced in the 2001 World Health Organization (WHO) classification to encompass cases of AML characterized by myelodysplastic syndrome-like features. The 2008 WHO classification revised this group into a new category, AML with myelodysplasia-related changes (AML-MRC). The category now includes patients with at least 20% blasts in peripheral blood or bone marrow and any of the following: (1) AML arising from a previous MDS or mixed MDS/myeloproliferative neoplasm, (2) AML with a specific MDS-associated cytogenetic abnormality and/or (3) AML with multilineage dysplasia. Up to 48% of all patients with AML are encompassed within the AML-MRC subgroup. AML-MRC patients have worse prognosis compared with patients with AML, not otherwise specified.

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KW - Acute myeloid leukemia

KW - Multilineage dysplasia

KW - Myelodysplasia-related changes

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Acute Myeloid Leukemia With Myelodysplasia-Related Changes: A New Definition

Abstract

Keywords

ASJC Scopus subject areas

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