Abstract
Objectives: Acute myeloid leukemia (AML) with monosomal karyotype (MK) recently has been reported to be associated with worse outcome than the traditional complex karyotype.
Methods: In this retrospective study of 111 patients with AML, we identified 14 patients with MK (13% of all patients with AML) using the definition proposed by Breems et al.
Results: Five (36%) of these 14 patients had a loss of a single chromosome in the presence of other structural abnormalities, and nine (64%) had a loss of two or more autosomal chromosomes. Patients with AML-MK presented at an older age, with lower bone marrow blasts, and their blasts less frequently expressed CD34. Most patients with AML-MK had morphologic multilineage dysplasia and were predominantly subclassified as having AML with myelodysplasia-related changes (AML-MRC). Molecular analysis showed a significant absence of NPM1 and FLT3 in patients with AML-MK.
Conclusions: Outcome data showed that patients with AML-MK had significantly worse overall survival, disease-free survival, and complete response compared with the rest of the patients with AML as well as within the AML-MRC group.
Original language | English (US) |
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Pages (from-to) | 190-195 |
Number of pages | 6 |
Journal | American journal of clinical pathology |
Volume | 142 |
Issue number | 2 |
DOIs | |
State | Published - Aug 1 2014 |
Externally published | Yes |
Keywords
- Acute myeloid leukemia
- Monosomal karyotype
- Myelodysplasia
ASJC Scopus subject areas
- Pathology and Forensic Medicine