Acute myeloid leukemia with monosomal karyotype: Morphologic, immunophenotypic, and molecular findings

Olga K. Weinberg, Robert S. Ohgami, Lisa Ma, Katie Seo, Li Ren, Jason R. Gotlib, Mahesh Seetharam, Athena Cherry, Daniel A. Arber

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Objectives: Acute myeloid leukemia (AML) with monosomal karyotype (MK) recently has been reported to be associated with worse outcome than the traditional complex karyotype.

Methods: In this retrospective study of 111 patients with AML, we identified 14 patients with MK (13% of all patients with AML) using the definition proposed by Breems et al.

Results: Five (36%) of these 14 patients had a loss of a single chromosome in the presence of other structural abnormalities, and nine (64%) had a loss of two or more autosomal chromosomes. Patients with AML-MK presented at an older age, with lower bone marrow blasts, and their blasts less frequently expressed CD34. Most patients with AML-MK had morphologic multilineage dysplasia and were predominantly subclassified as having AML with myelodysplasia-related changes (AML-MRC). Molecular analysis showed a significant absence of NPM1 and FLT3 in patients with AML-MK.

Conclusions: Outcome data showed that patients with AML-MK had significantly worse overall survival, disease-free survival, and complete response compared with the rest of the patients with AML as well as within the AML-MRC group.

Original languageEnglish (US)
Pages (from-to)190-195
Number of pages6
JournalAmerican journal of clinical pathology
Issue number2
StatePublished - Aug 1 2014
Externally publishedYes


  • Acute myeloid leukemia
  • Monosomal karyotype
  • Myelodysplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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