TY - JOUR
T1 - Acute effects of insulin on circulating natriuretic peptide levels in humans
AU - Bachmann, Katherine N.
AU - Deger, Serpil Muge
AU - Alsouqi, Aseel
AU - Huang, Shi
AU - Xu, Meng
AU - Ferguson, Jane F.
AU - Su, Yan Ru
AU - Niswender, Kevin D.
AU - Alp Ikizler, T.
AU - Wang, Thomas J.
N1 - Funding Information:
Research reported in this publication was supported by the American Heart Association awards (https://research.americanheart.org) 14SFRN20770008 (S.M.D., T.A.I.) and 15SDG24890015 (J.F.F.); the National Institutes of Health (https://www.nih.gov) Clinical Translational Science Award UL1TR000445 (T.A.I.) from the National Center for Advancing Translational Sciences, National Institute of Diabetes and Digestive and Kidney Diseases awards T32DK007061 (K.N.B.), P30 DK020593 (K.D.N.), K24 DK62849 (T.A.I.), and Vanderbilt O’Brien Mouse Kidney Center Grant P30 DK079341 (T.A. I.); National Heart, Lung, and Blood Institute award R01 HL102780 (T.J.W.); Vanderbilt University Medical Center Faculty Research Scholars award (http://my.vanderbilt.edu/vfrs) (K.N.B.), and U.S. Department of Veterans Affairs (https://www.research.va.gov/funding/) under Award Number 1I01CX000414 (T.A.I.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would like to thank Dr. Jens Titze for his review and support of the manuscript, and Kelsey Tomasek for running the natriuretic peptide assays.
Publisher Copyright:
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
PY - 2018/5
Y1 - 2018/5
N2 - Background The natriuretic peptide hormones play an important role in salt and blood pressure regulation. In observational studies, obesity and insulin resistance have been consistently associated with lower concentrations of natriuretic peptides. It has been proposed that insulin influences natriuretic peptide production. Objective We sought to determine the acute effects of insulin administration on natriuretic peptide concentrations. Methods 31 men and women (11 lean, 10 overweight, and 10 obese), ages 30–70 years, without cardiovascular disease or overt diabetes underwent a hyperinsulinemic-euglycemic insulin clamp. Plasma concentrations of N-terminal pro atrial natriuretic peptide (NT-proANP) and N-terminal pro B-type natriuretic peptide (NT-proBNP) were measured at baseline and steady-state (the final 30 minutes of the clamp protocol). Results From baseline to steady-state, insulin levels increased from a mean level of 9.5 to 176.7 μU/ml (p<0.001). Over this period, circulating NT-proANP concentrations decreased by 9% (-1933 ng/L, p = 0.01). The changes in NT-proANP did not differ between lean, overweight, and obese individuals. Steady-state NT-proANP levels, adjusted for baseline, were lower in individuals with greater insulin resistance, independent of BMI. In contrast to NT-proANP, NT-proBNP levels did not change significantly during the clamp (p = 0.41). Conclusion Insulin administration was associated with a moderate decrease in circulating NT-proANP, but not NT-proBNP. The lowest NT-proANP concentrations were found in insulin-resistant individuals. Further investigations are warranted to elucidate potential mechanisms underlying the effects of insulin on the cardiac hormonal axis.
AB - Background The natriuretic peptide hormones play an important role in salt and blood pressure regulation. In observational studies, obesity and insulin resistance have been consistently associated with lower concentrations of natriuretic peptides. It has been proposed that insulin influences natriuretic peptide production. Objective We sought to determine the acute effects of insulin administration on natriuretic peptide concentrations. Methods 31 men and women (11 lean, 10 overweight, and 10 obese), ages 30–70 years, without cardiovascular disease or overt diabetes underwent a hyperinsulinemic-euglycemic insulin clamp. Plasma concentrations of N-terminal pro atrial natriuretic peptide (NT-proANP) and N-terminal pro B-type natriuretic peptide (NT-proBNP) were measured at baseline and steady-state (the final 30 minutes of the clamp protocol). Results From baseline to steady-state, insulin levels increased from a mean level of 9.5 to 176.7 μU/ml (p<0.001). Over this period, circulating NT-proANP concentrations decreased by 9% (-1933 ng/L, p = 0.01). The changes in NT-proANP did not differ between lean, overweight, and obese individuals. Steady-state NT-proANP levels, adjusted for baseline, were lower in individuals with greater insulin resistance, independent of BMI. In contrast to NT-proANP, NT-proBNP levels did not change significantly during the clamp (p = 0.41). Conclusion Insulin administration was associated with a moderate decrease in circulating NT-proANP, but not NT-proBNP. The lowest NT-proANP concentrations were found in insulin-resistant individuals. Further investigations are warranted to elucidate potential mechanisms underlying the effects of insulin on the cardiac hormonal axis.
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U2 - 10.1371/journal.pone.0196869
DO - 10.1371/journal.pone.0196869
M3 - Article
C2 - 29758041
AN - SCOPUS:85046935343
SN - 1932-6203
VL - 13
JO - PloS one
JF - PloS one
IS - 5
M1 - e0196869
ER -