Activation of murine epidermal γδ T cells through surface 2B4

G. Schuhmachers, K. Ariizumi, P. A. Mathew, M. Bennett, V. Kumar, A. Takashima

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Dendritic epidermal T cells (DETC) are γδ T cells that normally reside in murine skin. They express on their surface the 2B4 molecule, a 66‐kDa glycoprotein of the immunoglobulin gene superfamily thought to be associated with anti‐tumor cytotoxicity by natural killer and lymphokine‐activated killer cells. Here, we show that ligation of surface 2B4 transduces cell activation signals in DETC. Treatment with anti‐2B4 monoclonal antibodies triggers the secretion of interferon‐γ and interleukin‐2 by DETC lines, induces proliferation of resting DETC lines, amplifies anti‐CD3‐dependent proliferation of DETC freshly isolated from mouse skin; and up‐regulates egr‐1 and c‐fos mRNA expression. These results indicate a unique pathway for DETC activation.

Original languageEnglish (US)
Pages (from-to)1117-1120
Number of pages4
JournalEuropean Journal of Immunology
Issue number4
StatePublished - Apr 1995


  • 2B4
  • Dendritic epidermal T cells
  • Signaling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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