Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins

Frank Medina; Angela M. Carter; Olugbenga Dada; Stephen Gutowski; Jana Hadas; Zhe Chen; Paul C. Sternweis

doi:10.1074/jbc.M113.450056

Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins

Frank Medina, Angela M. Carter, Olugbenga Dada, Stephen Gutowski, Jana Hadas, Zhe Chen, Paul C. Sternweis

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Background: Activated RhoA binds to the PH domain of its own GEF, PDZRhoGEF. Results: Activated RhoA binds to all Lbc RhoGEFs and provides positive feedback regulation to these regulators. Conclusion: Allosteric binding of activated RhoA to its own regulators facilitates other regulatory stimuli. Significance: This autoregulatory mechanism could mediate robust localized signaling and may represent a general paradigm for regulation of other monomeric GTPases.

Original language	English (US)
Pages (from-to)	11325-11333
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	288
Issue number	16
DOIs	https://doi.org/10.1074/jbc.M113.450056
State	Published - Apr 19 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "Background: Activated RhoA binds to the PH domain of its own GEF, PDZRhoGEF. Results: Activated RhoA binds to all Lbc RhoGEFs and provides positive feedback regulation to these regulators. Conclusion: Allosteric binding of activated RhoA to its own regulators facilitates other regulatory stimuli. Significance: This autoregulatory mechanism could mediate robust localized signaling and may represent a general paradigm for regulation of other monomeric GTPases.",

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AU - Medina, Frank

AU - Carter, Angela M.

AU - Dada, Olugbenga

AU - Gutowski, Stephen

AU - Hadas, Jana

AU - Chen, Zhe

AU - Sternweis, Paul C.

PY - 2013/4/19

Y1 - 2013/4/19

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AB - Background: Activated RhoA binds to the PH domain of its own GEF, PDZRhoGEF. Results: Activated RhoA binds to all Lbc RhoGEFs and provides positive feedback regulation to these regulators. Conclusion: Allosteric binding of activated RhoA to its own regulators facilitates other regulatory stimuli. Significance: This autoregulatory mechanism could mediate robust localized signaling and may represent a general paradigm for regulation of other monomeric GTPases.

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Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins

Abstract

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