Acrokeratosis Verruciformis (Hopf) and Darier's Disease: Genetic Evidence for a Unitary Origin

James H. Herndon; Jean D. Wilson

doi:10.1001/archderm.1966.01600210041006

Acrokeratosis Verruciformis (Hopf) and Darier's Disease: Genetic Evidence for a Unitary Origin

James H. Herndon, Jean D. Wilson

Internal Medicine

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28 Scopus citations

Abstract

Twelve members of a single family were found to exhibit a disorder of keratinization. Seven of these persons had findings characteristic of Ackrokeratosis Verruciformis (Hopf), one member or possibly two had Darier's disease, and three of the family had minor disturbances of keratinization. It was proposed that these disorders represent variable manifestations of a single underlying genetic defect in keratin formation.

Original language	English (US)
Pages (from-to)	305-310
Number of pages	6
Journal	Archives of Dermatology
Volume	93
Issue number	3
DOIs	https://doi.org/10.1001/archderm.1966.01600210041006
State	Published - Mar 1966

ASJC Scopus subject areas

Dermatology

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10.1001/archderm.1966.01600210041006

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title = "Acrokeratosis Verruciformis (Hopf) and Darier's Disease: Genetic Evidence for a Unitary Origin",

abstract = "Twelve members of a single family were found to exhibit a disorder of keratinization. Seven of these persons had findings characteristic of Ackrokeratosis Verruciformis (Hopf), one member or possibly two had Darier's disease, and three of the family had minor disturbances of keratinization. It was proposed that these disorders represent variable manifestations of a single underlying genetic defect in keratin formation.",

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AB - Twelve members of a single family were found to exhibit a disorder of keratinization. Seven of these persons had findings characteristic of Ackrokeratosis Verruciformis (Hopf), one member or possibly two had Darier's disease, and three of the family had minor disturbances of keratinization. It was proposed that these disorders represent variable manifestations of a single underlying genetic defect in keratin formation.

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Acrokeratosis Verruciformis (Hopf) and Darier's Disease: Genetic Evidence for a Unitary Origin

Abstract

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