Acquired Platelet Dysfunction

Yu Min P Shen, Eugene P. Frenkel

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


Acquired platelet dysfunction is encountered frequently in clinical practice. The usual clinical presentation is that of mucosal bleeding, epistaxis, or superficial epidermal bleeds. Often, the dysfunctional platelets are related to a medication or a systemic disorder. Normally, when platelets are exposed to damaged endothelium, they adhere to the exposed basement membrane collagen and change their shape from smooth disks to spheres with pseudopodia. Then, they secrete the contents of their granules, a process referred to as the release reaction. Additional platelets form aggregates on those platelets that have adhered to the vessel wall. As a result, the primary hemostatic plug is formed, and bleeding is arrested. This article reviews the various forms of acquired platelet dysfunction that result in decreased platelet aggregation, adhesion, or secretion.

Original languageEnglish (US)
Pages (from-to)647-661
Number of pages15
JournalHematology/Oncology Clinics of North America
Issue number4
StatePublished - Aug 2007

ASJC Scopus subject areas

  • Hematology
  • Oncology


Dive into the research topics of 'Acquired Platelet Dysfunction'. Together they form a unique fingerprint.

Cite this