Accuracy of Cardiac Magnetic Resonance Imaging in Diagnosing Pediatric Cardiac Masses: A Multicenter Study

Rebecca S. Beroukhim, Sunil Ghelani, Ravi Ashwath, Sowmya Balasubramanian, David M. Biko, Sujatha Buddhe, M. Jay Campbell, Russell Cross, Pierluigi Festa, Lindsay Griffin, Heynric Grotenhuis, Keren Hasbani, Sassan Hashemi, Sanjeet Hegde, Tarique Hussain, Supriya Jain, Maria Kiaffas, Shelby Kutty, Christopher Z. Lam, Gabriela LiberatoAnthony Merlocco, Nilanjana Misra, Katie L. Mowers, Juan Carlos Muniz, Arni Nutting, David A. Parra, Jyoti K. Patel, Antonio R. Perez-Atayde, Deepa Prasad, Carlos F. Rosental, Amee Shah, Margaret M. Samyn, Lynn A. Sleeper, Timothy Slesnick, Emanuela Valsangiacomo, Tal Geva

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: After diagnosis of a cardiac mass, clinicians must weigh the benefits and risks of ascertaining a tissue diagnosis. Limited data are available on the accuracy of previously developed noninvasive pediatric cardiac magnetic resonance (CMR)-based diagnostic criteria. Objectives: The goals of this study were to: 1) evaluate the CMR characteristics of pediatric cardiac masses from a large international cohort; 2) test the accuracy of previously developed CMR-based diagnostic criteria; and 3) expand diagnostic criteria using new information. Methods: CMR studies (children 0-18 years of age) with confirmatory histological and/or genetic diagnosis were analyzed by 2 reviewers, without knowledge of prior diagnosis. Diagnostic accuracy was graded as: 1) single correct diagnosis; 2) correct diagnosis among a differential; or 3) incorrect diagnosis. Results: Of 213 cases, 174 (82%) had diagnoses that were represented in the previously published diagnostic criteria. In 70% of 174 cases, both reviewers achieved a single correct diagnosis (94% of fibromas, 71% of rhabdomyomas, and 50% of myxomas). When ≤2 differential diagnoses were included, both reviewers reached a correct diagnosis in 86% of cases. Of 29 malignant tumors, both reviewers indicated malignancy as a single diagnosis in 52% of cases. Including ≤2 differential diagnoses, both reviewers indicated malignancy in 83% of cases. Of 6 CMR sequences examined, acquisition of first-pass perfusion and late gadolinium enhancement were independently associated with a higher likelihood of a single correct diagnosis. Conclusions: CMR of cardiac masses in children leads to an accurate diagnosis in most cases. A comprehensive imaging protocol is associated with higher diagnostic accuracy.

Original languageEnglish (US)
Pages (from-to)1391-1405
Number of pages15
JournalJACC: Cardiovascular Imaging
Issue number8
StatePublished - Aug 2022
Externally publishedYes


  • cardiac magnetic resonance
  • cardiac mass
  • cardiac tumor
  • pediatric

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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