Accelerated five-dimensional echo planar J-resolved spectroscopic imaging: Implementation and pilot validation in human brain

Neil E. Wilson, Zohaib Iqbal, Brian L. Burns, Margaret Keller, M. Albert Thomas

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Purpose To implement an accelerated five-dimensional (5D) echo-planar J-resolved spectroscopic imaging sequence combining 3 spatial and 2 spectral encoding dimensions and to apply the sequence in human brain. Methods An echo planar readout was used to acquire a single spatial and a single spectral dimension during one readout. Nonuniform sampling was applied to the two phase-encoded spatial directions and the indirect spectral dimension. Nonlinear reconstruction was used to minimize the ℓ1-norm or the total variation and included a spectral mask to enhance sparsity. Retrospective reconstructions at multiple undersamplings were performed in phantom. Ten healthy volunteers were scanned with 8× undersampling and compared to a fully sampled single slice scan. Results Retrospective reconstruction of fully sampled phantom data showed excellent quality at 4×, 8×, 12×, and 16× undersampling using either reconstruction method. Reconstruction of prospectively acquired in vivo scans with 8× undersampling showed excellent quality in the occipito-parietal lobes and good quality in the frontal lobe, consistent with the fully sampled single slice scan. Conclusion By utilizing nonuniform sampling with nonlinear reconstruction, 2D J-resolved spectra can be acquired over a 3D spatial volume with a total scan time of 20 min, which is reasonable for in vivo studies.

Original languageEnglish (US)
Pages (from-to)42-51
Number of pages10
JournalMagnetic resonance in medicine
Issue number1
StatePublished - Jan 1 2016
Externally publishedYes


  • 3D spectroscopic imaging
  • J-resolved spectroscopic imaging
  • compressed sensing
  • echo-planar J-resolved spectroscopic imaging
  • human brain
  • nonuniform sampling

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Accelerated five-dimensional echo planar J-resolved spectroscopic imaging: Implementation and pilot validation in human brain'. Together they form a unique fingerprint.

Cite this