@article{14c44b31b951439fa6b873ad9a0b3a7f,
title = "Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE",
abstract = "A novel polymorphism (-491 A/T) within the regulatory region on the apolipoprotein E gene has recently been reported to be associated with risk for Alzheimer disease (AD). To test this association in an independent data set, we have examined this polymorphism in a sample of 88 well-characterized AD cases and compared the allele frequency and genotype frequencies for this polymorphism with those observed in 112 cegnitively normal subjects drawn from the same ethnic group. These results suggest that in the current data set at least, the -491 NT polymorphism is not associated with risk for AD, but may be in partial linkage disequilibrium with the APOE ε2/ε3/ε4 polymorphism.",
keywords = "-491 A/T polymorphism, APOE ε2/ε3/ε4 polymorphism, Alzheimer disease",
author = "Song, {Y. Q.} and E. Rogaeva and S. Premkumar and N. Brindle and T. Kawarai and An Orlacchio and G. Yu and G. Levesque and M. Nishimura and M. Ikeda and Y. Pei and C. O'Toole and R. Duara and W. Barker and S. Sorbi and M. Freedman and L. Farrer and {St. George-Hyslop}, P.",
note = "Funding Information: This work was supported by grants from the Medical Research Council of Canada, The Canadian Genetic Diseases Network, The Alzheimer Association of Ontario, The Howard Hughes Medical Research Foundation, the EJLB Foundation, the National Institutes of Health (AG09029), the Peter Burgess Fellowship (E.R.), the Alzheimer Society of Canada Fellowship (G.L.), the Helen B. Hunter Fellowship (G.Y.), the National Institutes of Health (T32-AG00115) (S.P). ",
year = "1998",
month = jul,
day = "10",
doi = "10.1016/S0304-3940(98)00470-4",
language = "English (US)",
volume = "250",
pages = "189--192",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",
}