Absence of a pyrimidine dimer repair mechanism for mitochondrial DNA in mouse and human cells.

D. A. Clayton; J. N. Doda; E. C. Friedberg

Absence of a pyrimidine dimer repair mechanism for mitochondrial DNA in mouse and human cells.

D. A. Clayton, J. N. Doda, E. C. Friedberg

Research output: Contribution to journal › Article › peer-review

Abstract

We have assayed the ability of mammalian cells to remove pyrimidine dimers from their mitochondrial DNA. The results indicate that pyrimidine dimers are not repaired for as long as 48 hr after UV irradiation. Furthermore, molecules containing pyrimidine dimers are unable to replicate and are simply diluted out in subsequent cell divisions.

Original language	English (US)
Pages (from-to)	589-591
Number of pages	3
Journal	Basic life sciences
Volume	5 B
State	Published - Dec 1 1975

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "Absence of a pyrimidine dimer repair mechanism for mitochondrial DNA in mouse and human cells.",

abstract = "We have assayed the ability of mammalian cells to remove pyrimidine dimers from their mitochondrial DNA. The results indicate that pyrimidine dimers are not repaired for as long as 48 hr after UV irradiation. Furthermore, molecules containing pyrimidine dimers are unable to replicate and are simply diluted out in subsequent cell divisions.",

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AU - Friedberg, E. C.

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AB - We have assayed the ability of mammalian cells to remove pyrimidine dimers from their mitochondrial DNA. The results indicate that pyrimidine dimers are not repaired for as long as 48 hr after UV irradiation. Furthermore, molecules containing pyrimidine dimers are unable to replicate and are simply diluted out in subsequent cell divisions.

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Absence of a pyrimidine dimer repair mechanism for mitochondrial DNA in mouse and human cells.

Abstract

ASJC Scopus subject areas

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