Abnormalities of the corpus callosum in first episode, treatment naive schizophrenia

M. S. Keshavan, V. A. Diwadkar, K. Harenski, D. R. Rosenberg, J. A. Sweeney, J. W. Pettegrew

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


Background: Structural alterations in the association cortices as well as in the corpus callosum (CC) have been described in schizophrenia, and have been considered to reflect developmental abnormalities. Areas of primary and association cortices have been topographically mapped in the CC. Objective: To investigate whether, in schizophrenia, there are alterations in CC subdivisions that connect association, but not primary, cortices, and also to see if the normative, developmentally mediated increase in CC size with age is absent in this disorder. Methods: The midsagittal magnetic resonance imaging scans of 31 first episode, neuroleptic naive, schizophrenic patients, 12 non-schizophrenic, psychotic patients, and 31 healthy controls were compared. The total area of CC as well as that of anterior, middle and posterior genu, body, Risthmus, and anterior, middle, and posterior splenii were measured. Results: Patients with schizophrenia as a group had a smaller CC, anterior genu, anterior body, isthmus, and anterior splenium than normal controls. Furthermore, the age related increase in CC size seen in normal subjects was absent in the patients. Conclusions: The observed reductions in size in selected regions of CC suggest a reduction in axonal connections between the heteromodal association cortices, which typically involve small diameter fibres. Furthermore, the absence of an age related increase in CC size in patients with schizophrenia suggests a neurodevelopmental abnormality that may extend into adolescence and early adulthood.

Original languageEnglish (US)
Pages (from-to)757-760
Number of pages4
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number6
StatePublished - 2002

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health


Dive into the research topics of 'Abnormalities of the corpus callosum in first episode, treatment naive schizophrenia'. Together they form a unique fingerprint.

Cite this