Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma

Keyphrases

• Hepatocellular Carcinoma 100%
• Ku70 100%
• Phosphorylation Sites 100%
• DNA Damage Repair 100%
• Ablating 100%
• Spontaneous Induction 100%
• Defective DNA 100%
• Littermate 25%
• Genomic Instability 25%
• Double-strand Breaks 25%
• Double-strand Break Repair 25%
• Tumor 12%
• Attenuation 12%
• Knock-in Mouse Model 12%
• Radiosensitive 12%
• Phosphorylation 12%
• Non-homologous End Joining 12%
• Homologous Recombination 12%
• Tumorigenesis 12%
• DNA Repair 12%
• DNA Double-strand Breaks 12%
• Mitomycin C 12%
• Multiple Pathways 12%
• Transformed Cells 12%
• H2AX 12%
• Chemically Induced 12%
• Accelerated Development 12%
• DNA Crosslinking Agents 12%
• 8-oxoguanine 12%
• DNA End Resection 12%
• Repair Pathway Choice 12%

Medicine and Dentistry

• Hepatocellular Carcinoma 100%
• DNA Repair 100%
• Genomic Instability 50%
• Neoplasm 25%
• Surgery 25%
• Alanine 25%
• Carcinogenesis 25%
• Double Stranded DNA 25%
• Non-Homologous End Joining 25%
• Mitomycin 25%
• Homologous Recombination 25%
• Transformed Cell Line 25%
• DNA Cross Linking 25%

Biochemistry, Genetics and Molecular Biology

• DNA Repair 100%
• Ku70 100%
• Mouse 50%
• Genome Instability 25%
• Alanine 12%
• Wild Type 12%
• Carcinogenesis 12%
• Non-Homologous End Joining 12%
• Homologous Recombination 12%
• Dynamics 12%
• Crosslinking of DNA 12%