@article{adc3b80d38cf4eb3b9fe8e7356ed2ed8,
title = "Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline",
abstract = "Acute seizures after a severe brain insult can often lead to epilepsy and cognitive impairment. Aberrant hippocampal neurogenesis follows the insult but the role of adult-generated neurons in the development of chronic seizures or associated cognitive deficits remains to be determined. Here we show that the ablation of adult neurogenesis before pilocarpine-induced acute seizures in mice leads to a reduction in chronic seizure frequency. We also show that ablation of neurogenesis normalizes epilepsy-associated cognitive deficits. Remarkably, the effect of ablating adult neurogenesis before acute seizures is long lasting as it suppresses chronic seizure frequency for nearly 1 year. These findings establish a key role of neurogenesis in chronic seizure development and associated memory impairment and suggest that targeting aberrant hippocampal neurogenesis may reduce recurrent seizures and restore cognitive function following a pro-epileptic brain insult.",
author = "Cho, {Kyung Ok} and Lybrand, {Zane R.} and Naoki Ito and Rebecca Brulet and Farrah Tafacory and Ling Zhang and Levi Good and Kerstin Ure and Kernie, {Steven G.} and Birnbaum, {Shari G} and Scharfman, {Helen E.} and Eisch, {Amelia J} and Jenny Hsieh",
note = "Funding Information: This work was supported by the National Institutes of Health (NIH) grants (R01AG032383, R01NS076775, R01NS038572 and K02AG041815 to J.H.; R01NS081203 to J.H. and H.E.S.; R01DA016765 and K02DA023555 to A.J.E.), a grant from the National Aeronautics and Atmospheric Association (NASA; NX12AB55G to A.J.E.), American Heart Association training grant (5T32HL007360-34) to Z.R.L. and NIH predoctoral training grant (5T32GM083831-05) to R.B. This work was also supported by a grant from the Texas Institute for Brain Injury and Repair at UT Southwestern and the Welch Foundation I-1660 (to J.H.). The UTSW EEG Core facility is supported by the Haggerty Center for Brain Injury and Repair. We thank Dr Klaus-Armin Nave for providing NeuroDloxP/loxP mice, Dr Karyn Frick for behavioral consultation, Dr Chun-Li Zhang for valuable comments on the manuscript and Jingfei Zhu, Jing Ma, Bishakha Mona and Yixuan Tong for their technical help. We also thank Jose Cabrera for graphics support. Publisher Copyright: {\textcopyright} 2015 Macmillan Publishers Limited.",
year = "2015",
month = mar,
doi = "10.1038/ncomms7606",
language = "English (US)",
volume = "6",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
}