Abate and Switch: miR-145 in Stem Cell Differentiation

Raghu R. Chivukula; Joshua T. Mendell

doi:10.1016/j.cell.2009.04.059

Abate and Switch: miR-145 in Stem Cell Differentiation

Raghu R. Chivukula, Joshua T. Mendell

Research output: Contribution to journal › Short survey › peer-review

36 Scopus citations

Abstract

MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program.

Original language	English (US)
Pages (from-to)	606-608
Number of pages	3
Journal	Cell
Volume	137
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2009.04.059
State	Published - May 15 2009

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2009.04.059

Cite this

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title = "Abate and Switch: miR-145 in Stem Cell Differentiation",

abstract = "MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program.",

author = "Chivukula, {Raghu R.} and Mendell, {Joshua T.}",

year = "2009",

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T2 - miR-145 in Stem Cell Differentiation

AU - Chivukula, Raghu R.

AU - Mendell, Joshua T.

PY - 2009/5/15

Y1 - 2009/5/15

N2 - MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program.

AB - MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program.

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VL - 137

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JO - Cell

JF - Cell

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Abate and Switch: miR-145 in Stem Cell Differentiation

Abstract

ASJC Scopus subject areas

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