@article{d46aa7b607ca45a9b975d267ed97bc1a,
title = "A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis",
abstract = "B cells isolated from the CSF of patients with multiple sclerosis (MS) have a unique accumulation of somatic hypermutation within the B cell receptor, termed the antibody gene signature (AGS). The focus of this study was to investigate whether the AGS could also be detected in MS brain tissue. Genetic analysis of B cells isolated from post-mortem CNS tissue samples from four MS brains demonstrated that signature enriched B cells are present at the site of tissue injury as well as in the circulating CSF.",
keywords = "Antibody gene rearrangement, B lymphocytes, CNS tissue, Multiple sclerosis, Somatic hypermutation",
author = "Ligocki, {A. J.} and L. Lovato and D. Xiang and P. Guidry and Scheuermann, {R. H.} and Willis, {S. N.} and S. Almendinger and Racke, {M. K.} and Elliot Frohman and Hafler, {D. A.} and O'Connor, {K. C.} and Monson, {Nancy L}",
note = "Funding Information: This study was supported by grants from the National Multiple Sclerosis Society to NLM ( RG3267 ) and DAH ( RG2172 and RG3308 ), and the National Institute of Health to RHS ( N01AI40041 ) and DAH ( U01DK6192601 , R01NS024247 , P01AI39671 , and P01NS38037 ). L.L. was supported by a training research fellowship FISM – Fondazione Italiana Sclerosi Multipla – Cod. 2008/B/3. S.N.W. is supported by a C. J. Martin Postdoctoral Fellowship from the National Health and Medical Research Council of Australia . K.C.O. was supported by a Career Transition Fellowship from the National Multiple Sclerosis Society . The authors have no conflicting financial interests. ",
year = "2010",
month = sep,
doi = "10.1016/j.jneuroim.2010.06.016",
language = "English (US)",
volume = "226",
pages = "192--193",
journal = "Advances in Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",
}