A tailored smoking, alcohol, and depression intervention for head and neck cancer patients

Sonia A. Duffy, David L. Ronis, Marcia Valenstein, Michael T. Lambert, Karen E. Fowler, Lynn Gregory, Carol Bishop, Larry L. Myers, Frederic C. Blow, Jeffrey E. Terrell

Research output: Contribution to journalArticlepeer-review

168 Scopus citations


Background: Smoking, alcohol use, and depression are interrelated and highly prevalent in patients with head and neck cancer, adversely affecting quality of life and survival. Smoking, alcohol, and depression share common treatments, such as cognitive behavioral therapy and antidepressants. Consequently, we developed and tested a tailored smoking, alcohol, and depression intervention for patients with head and neck cancer. Methods: Patients with head and neck cancer with at least one of these disorders were recruited from the University of Michigan and three Veterans Affairs medical centers. Subjects were randomized to usual care or nurse-administered intervention consisting of cognitive behavioral therapy and medications. Data collected included smoking, alcohol use, and depressive symptoms at baseline and at 6 months. Results: The mean age was 57 years. Most participants were male (84%) and White (90%). About half (52%) were married, 46% had a high school education or less, and 52% were recruited from Veterans Affairs sites. The sample was fairly evenly distributed across three major head and neck cancer sites and over half (61%) had stage III/IV cancers. Significant differences in 6-month smoking cessation rates were noted with 47% quitting in the intervention compared with 31% in usual care (P < 0.05). Alcohol and depression rates improved in both groups, with no significant differences in 6-month depression and alcohol outcomes. Conclusion: Treating comorbid smoking, problem drinking, and depression may increase smoking cessation rates above that of usual care and may be more practical than treating these disorders separately.

Original languageEnglish (US)
Pages (from-to)2203-2208
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Issue number11
StatePublished - Nov 2006

ASJC Scopus subject areas

  • Epidemiology
  • Oncology


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