A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling

Medicine & Life Sciences

• Acetate-CoA Ligase 100%
• endothelial PAS domain-containing protein 1 95%
• Acetates 58%
• Mutation 33%
• Acetylation 27%
• Proteins 21%
• Acetyl Coenzyme A 17%
• Oxygen 14%
• Nuclear Localization Signals 8%
• Acetyltransferases 8%
• Hypoxia-Inducible Factor 1 8%
• Glucose 8%
• Clustered Regularly Interspaced Short Palindromic Repeats 7%
• Erythropoietin 6%
• Missense Mutation 6%
• Protein Domains 6%
• Mutagenesis 6%
• Proteolysis 6%
• Anemia 5%
• Hypoxia 5%
• Transcription Factors 4%
• Alleles 4%
• Neoplasms 4%
• Phenotype 3%
• DNA 3%
• Growth 3%
• Genes 2%