A subsequent-memory effect in dorsolateral prefrontal cortex

Bart Rypma, Mark D'Esposito

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


The importance of brain regions for long-term memory encoding has been examined by comparison of encoding-related neural activity on trials in which successful recollection subsequently occurred to the encoding-related activity on trials in which successful recollection did not occur. We applied similar analyses to event-related functional magnetic resonance imaging (fMRI) data to explore the relative roles of dorsolateral and ventrolateral prefrontal cortex (PFC) regions during specific components of a working-memory (WM) maintenance task. The results of this study indicated that increases in dorsolateral PFC activity during encoding was related to subsequent retrieval-success. These results lend support to the hypothesis that ventrolateral PFC mediates a limited-capacity WM buffer that supports rehearsal maintenance functions while dorsolateral PFC mediates WM organization functions that accommodate the capacity limits of WM maintenance.

Original languageEnglish (US)
Pages (from-to)162-166
Number of pages5
JournalCognitive Brain Research
Issue number2
StatePublished - Apr 2003


  • Functional magnetic resonance imaging
  • Prefrontal cortex
  • Subsequent-memory effect
  • Working memory

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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