A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

Nazar Mashtalir; Hiroshi Suzuki; Daniel P. Farrell; Akshay Sankar; Jie Luo; Martin Filipovski; Andrew R. D'Avino; Roodolph St. Pierre; Alfredo M. Valencia; Takashi Onikubo; Robert G. Roeder; Yan Han; Yuan He; Jeffrey A. Ranish; Frank DiMaio; Thomas Walz; Cigall Kadoch

doi:10.1016/j.cell.2020.09.051

A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

Nazar Mashtalir, Hiroshi Suzuki, Daniel P. Farrell, Akshay Sankar, Jie Luo, Martin Filipovski, Andrew R. D'Avino, Roodolph St. Pierre, Alfredo M. Valencia, Takashi Onikubo, Robert G. Roeder, Yan Han, Yuan He, Jeffrey A. Ranish, Frank DiMaio, Thomas Walz, Cigall Kadoch

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Structural analysis of an endogenous human SWI/SNF complex shows how it engages with nucleosomes and provides insight into how cancer-associated mutations affect the remodeler's function.

Original language	English (US)
Pages (from-to)	802-817.e24
Journal	Cell
Volume	183
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2020.09.051
State	Published - Oct 29 2020
Externally published	Yes

Keywords

ATP-dependent chromatin remodeling
BAF complex
cancer
cross-linking mass spectrometry
cryoelectron microscopy
homology modeling
mammalian SWI/SNF complexes
mutations

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2020.09.051

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Mashtalir, N., Suzuki, H., Farrell, D. P., Sankar, A., Luo, J., Filipovski, M., D'Avino, A. R., St. Pierre, R., Valencia, A. M., Onikubo, T., Roeder, R. G., Han, Y., He, Y., Ranish, J. A., DiMaio, F., Walz, T., & Kadoch, C. (2020). A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms. Cell, 183(3), 802-817.e24. https://doi.org/10.1016/j.cell.2020.09.051

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abstract = "Structural analysis of an endogenous human SWI/SNF complex shows how it engages with nucleosomes and provides insight into how cancer-associated mutations affect the remodeler's function.",

keywords = "ATP-dependent chromatin remodeling, BAF complex, cancer, cross-linking mass spectrometry, cryoelectron microscopy, homology modeling, mammalian SWI/SNF complexes, mutations",

author = "Nazar Mashtalir and Hiroshi Suzuki and Farrell, {Daniel P.} and Akshay Sankar and Jie Luo and Martin Filipovski and D'Avino, {Andrew R.} and {St. Pierre}, Roodolph and Valencia, {Alfredo M.} and Takashi Onikubo and Roeder, {Robert G.} and Yan Han and Yuan He and Ranish, {Jeffrey A.} and Frank DiMaio and Thomas Walz and Cigall Kadoch",

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year = "2020",

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doi = "10.1016/j.cell.2020.09.051",

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AU - Mashtalir, Nazar

AU - Suzuki, Hiroshi

AU - Farrell, Daniel P.

AU - Sankar, Akshay

AU - Luo, Jie

AU - Filipovski, Martin

AU - D'Avino, Andrew R.

AU - St. Pierre, Roodolph

AU - Valencia, Alfredo M.

AU - Onikubo, Takashi

AU - Roeder, Robert G.

AU - Han, Yan

AU - He, Yuan

AU - Ranish, Jeffrey A.

AU - DiMaio, Frank

AU - Walz, Thomas

AU - Kadoch, Cigall

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N2 - Structural analysis of an endogenous human SWI/SNF complex shows how it engages with nucleosomes and provides insight into how cancer-associated mutations affect the remodeler's function.

AB - Structural analysis of an endogenous human SWI/SNF complex shows how it engages with nucleosomes and provides insight into how cancer-associated mutations affect the remodeler's function.

KW - ATP-dependent chromatin remodeling

KW - BAF complex

KW - cancer

KW - cross-linking mass spectrometry

KW - cryoelectron microscopy

KW - homology modeling

KW - mammalian SWI/SNF complexes

KW - mutations

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A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

Abstract

Keywords

ASJC Scopus subject areas

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