Abstract
Bleach oxidizes trimethylsilyl cyanide to generate an electrophilic cyanating reagent that readily reacts with an amine nucleophile. This oxidative N-cyanation reaction allows for the preparation of disubstituted cyanamides from amines without using highly toxic cyanogen halides.
Original language | English (US) |
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Pages (from-to) | 247-249 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 16 |
Issue number | 1 |
DOIs | |
State | Published - Jan 3 2014 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry