A Sense of Self: RIG-I's Tolerance to Host RNA

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations


The innate immune sensor RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA. In this issue of Immunity, Schuberth-Wagner etal. (2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downstream activation.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
Issue number1
StatePublished - Jul 21 2015

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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