The innate immune sensor RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA. In this issue of Immunity, Schuberth-Wagner etal. (2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downstream activation.
|Original language||English (US)|
|Number of pages||2|
|State||Published - Jul 21 2015|
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases