Abstract
OBJECTIVE: To determine whether oral creatine produces positive changes in any of 4 outcomes in children with spinal muscular atrophy (SMA). METHODS: The authors conducted a randomized, double-blind, placebo-controlled trial on 55 patients aged 2-18 years with SMA. Patients aged younger than 5 years received 2 g/day of creatine/placebo for 6 months. Patients aged 5 years and older received 5 g/day. The primary outcome measure was the Gross Motor Function Measure (GMFM). Secondary outcome measures were Quantitative Muscle Testing (QMT), Parent Questionnaire for the PedsQL™ Neuromuscular Module (QOL), and Pulmonary Function Tests (PFT). RESULTS: Forty of the 55 patients completed the protocol. There was no significant difference in the 4 outcome measures between creatine and placebo groups. CONCLUSIONS: Under the experimental conditions of our study, creatine supplementation for 6 months did not improve motor function, muscle strength, pulmonary function, or quality of life in children with SMA.
Original language | English (US) |
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Pages (from-to) | 101-110 |
Number of pages | 10 |
Journal | Journal of Clinical Neuromuscular Disease |
Volume | 8 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2007 |
Keywords
- Creatine
- Spinalmuscular atrophy (SMA)
ASJC Scopus subject areas
- Neurology
- Clinical Neurology