A radioimmunoassay for plasma aldosterone by immunologic purification

C. Gomez-Sanchez, D. C. Kem, Norman M Kaplan

Research output: Contribution to journalArticlepeer-review

96 Scopus citations


A method for measuring aldosterone concentration has been improved by extracting the steroid from plasma with an antibody prior to radioimmunoassay. Precision, sensitivity and specificity were comparable in our laboratory to a method using paper chormatography and to published data for other methods. Duplicate specimens assayed with both methods gave a correlation of r = 0.91 (p < 0.005). This method eliminates chromatography and enables one technician to process 80-120 specimens each week.

Original languageEnglish (US)
Pages (from-to)795-798
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Issue number4
StatePublished - Apr 1973

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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