@article{460d65d4df094be8a42a9d7f749b4c01,
title = "A pilot study of magnetic seizure therapy for treatment-resistant obsessive–compulsive disorder",
abstract = "Background: There is growing interest in the potential of neuromodulation options in treatment-resistant obsessive–compulsive disorder (OCD). Magnetic seizure therapy (MST), is a new treatment intervention in which generalized seizures are induced with transcranial magnetic stimulation. We conducted a pilot study to assess the efficacy and cognitive effects of MST in patients with treatment-resistant OCD. Methods: In an open-label pilot study, participants with treatment-resistant OCD and a baseline Yale-Brown Obsessive–Compulsive Scale (Y-BOCS) scores of ≥16 were treated with up to 24 acute treatments. The primary clinical outcomes were clinical response (Y-BOCS score reduction ≥30%) and remission (final Y-BOCS score ≤8). A neurocognitive battery, the Quick Inventory for Depressive Symptoms–Self Report (QIDS-SR), the Beck Scale for Suicidal Ideation (SSI), and the Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF) were also completed as secondary measures. Results: Ten participants with OCD who had not responded to medications or psychotherapy enrolled in the study and seven completed an adequate trial (defined as ≥8 treatments). MST was associated with minimal cognitive effects except for some decrease in autobiographical memory and no serious adverse effects. Only one participant met the predefined criteria for response, and none for remission. The baseline and endpoint Y-BOCS scores were not statistically different. Conclusion: Overall, MST was not beneficial in a small group of patients with treatment-resistant OCD. At this time, other studies of MST for OCD are not warranted until different coil placements targeting other brain circuits can be proposed.",
keywords = "electroconvulsive therapy, magnetic seizure therapy, obsessive–compulsive disorder",
author = "Tang, {Victor M.} and Blumberger, {Daniel M.} and Weissman, {Cory R.} and Julia Dimitrova and Alanah Throop and McClintock, {Shawn M.} and Daphne Voineskos and Rajji, {Tarek K.} and Jonathan Downar and Yuliya Knyahnytska and Mulsant, {Benoit H.} and Fitzgerald, {Paul B.} and Daskalakis, {Zafiris J.}",
note = "Funding Information: Dr. Daniel M. Blumberger reports nonfinancial support from Brainsway and Magventure, grants from CIHR, Brain Canada, and NIH, outside the submitted work. Dr. Shawn M. McClintock reports consulting for Pearson Assessment, grants from NIH, outside the submitted work. Dr. Daphne Voineskos reports grants from the Ontario Mental Health Foundation, from the Innovation Fund of the Alternate Funding Plan for the Academic Health Sciences Centres of Ontario, outside the submitted work. Dr. Jonathan Downar reports personal fees from Restorative Brain Clinics, personal fees from TMS Neuro Health, personal fees from Neurostim TMS Clinics, outside the submitted work. Dr. Benoit H. Mulsant reports grants from Brain Canada, Canadian Institutes of Health Research, Centre for Addiction and Mental Health (CAMH) Foundation, Patient‐Centred Outcomes Research Institute (PCORI), and US National Institutes of Health, nonfinancial support from Eli Lilly, Pfizer, Capital Solutions Design LLC, and HAPPYneuron, directly owning stocks from General Electric, outside the submitted work. Dr. Paul B. Fitzgerald reports equipment for research from Magventure, Nexstim, and Brainsway, outside the submitted work. Dr. Zafiris J. Daskalakis reports grants from Brainsway Inc., grants from Magventure Inc., grants from Ontario Mental Health Foundation, outside the submitted work. The remaining authors declare that there are no conflict of interests. Funding Information: This study was supported by the Temerty Family and the Grant Family and through the Centre for Addiction and Mental Health (CAMH) Foundation and the Campbell Institute. Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals LLC",
year = "2021",
month = feb,
doi = "10.1002/da.23097",
language = "English (US)",
volume = "38",
pages = "161--171",
journal = "Anxiety",
issn = "1091-4269",
publisher = "Wiley-Blackwell",
number = "2",
}