A one and a two ... expanding roles for poly(ADP-ribose) polymerases in metabolism

Xin Luo; W. Lee Kraus

doi:10.1016/j.cmet.2011.03.011

A one and a two ... expanding roles for poly(ADP-ribose) polymerases in metabolism

Xin Luo, W. Lee Kraus

Research output: Contribution to journal › Short survey › peer-review

21 Scopus citations

Abstract

In two related papers in this issue, Bai et al. (2011a, 2011b) observe that PARP-1- or PARP-2-deficient mice show increased energy expenditure and protection against diet-induced obesity. This metabolic phenotype is achieved, in part, through SIRT1 activation, either by increasing NAD ⁺ levels or by promoting SIRT1 expression.

Original language	English (US)
Pages (from-to)	353-355
Number of pages	3
Journal	Cell Metabolism
Volume	13
Issue number	4
DOIs	https://doi.org/10.1016/j.cmet.2011.03.011
State	Published - Apr 6 2011

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2011.03.011

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title = "A one and a two ... expanding roles for poly(ADP-ribose) polymerases in metabolism",

abstract = " In two related papers in this issue, Bai et al. (2011a, 2011b) observe that PARP-1- or PARP-2-deficient mice show increased energy expenditure and protection against diet-induced obesity. This metabolic phenotype is achieved, in part, through SIRT1 activation, either by increasing NAD + levels or by promoting SIRT1 expression.",

author = "Xin Luo and Kraus, {W. Lee}",

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AU - Luo, Xin

AU - Kraus, W. Lee

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N2 - In two related papers in this issue, Bai et al. (2011a, 2011b) observe that PARP-1- or PARP-2-deficient mice show increased energy expenditure and protection against diet-induced obesity. This metabolic phenotype is achieved, in part, through SIRT1 activation, either by increasing NAD + levels or by promoting SIRT1 expression.

AB - In two related papers in this issue, Bai et al. (2011a, 2011b) observe that PARP-1- or PARP-2-deficient mice show increased energy expenditure and protection against diet-induced obesity. This metabolic phenotype is achieved, in part, through SIRT1 activation, either by increasing NAD + levels or by promoting SIRT1 expression.

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DO - 10.1016/j.cmet.2011.03.011

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JO - Cell Metabolism

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ER -

A one and a two ... expanding roles for poly(ADP-ribose) polymerases in metabolism

Abstract

ASJC Scopus subject areas

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