TY - JOUR
T1 - A novel microporous polyurethane vascular graft
T2 - In vivo evaluation of the UTA prosthesis implanted as infra-renal aortic substitute in dogs
AU - Marois, Yves
AU - Akoum, Ali
AU - King, Martin
AU - Guidoin, Robert
AU - Maltzahn, Wolf Von
AU - Kowligi, Rajagopal
AU - Eberhart, Robert C.
AU - Teijeira, Francisco Javier
AU - Verreault, Jean
N1 - Funding Information:
This work was supported by the MRC of Canada grant (RG) and USPHS grant R15-HL38743.01 (WvM). The authors are indebted to K. Horth, N. Massicotte, S. Bourassa, and G. Mongrain for their technical assistance. The authors extend their gratitude to T. How, J. Bianco, H. Vega, D. Boyer, and M. Therrien for help and guidance. The sutures were kindly provided by Ethicon. the antibiotics by Schering, and the heparin by Allen and Hanburys.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1993
Y1 - 1993
N2 - A novel microporous polyurethane blood conduit developed at the University of Texas at Arlington was implanted as an infra-renal substitute in dogs. The prosthesis was fabricated by precipitating a solution of the polymer with dry nitrogen onto a rotating mandrel. The grafts were sterilized either by gamma radiation (series I) or ethylene oxide (series II); they were implanted for the following prescheduled periods: 4, 24, 48 hours, and J week (short-term) and 2, 4 weeks, 3 and 6 months (medium-term). The thrombohematological characteristics of each animal were evaluated prior to implantation and confirmed that the index of blood coagulability was normal. In the short-term group, five out of eight grafts were patent and three were partially occluded; four grafts in the medium-term group were patent; one was partially occluded; and three were thrombosed at retrieval. One week after implantation, the prostheses were surrounded by an external capsule, which was present mainly at the two anastomoses. The external capsule covered the entire graft at 3 months. No kinking of the grafts was observed and the presence of a mild yellow stain related to bilirubin uptake was detected at 2 weeks, 1, 3, and 6 months. Histological studies have revealed the formation of a thin internal capsule at both anastomoses, 2 weeks postimplantation, which was not anchored to the graft wall. In the medium-term group, the thrombosed grafts failed to develop an internal capsule, whereas the patent graft exhibited a thick internal capsule made of neocollagenous tissue over the entire graft. This new microporous polyurethane prosthesis did not perform satisfactorily as an infra-renal substitute in dogs and its in vivo stability requires further assessment. Thus, the concept of a polyurethane with closed pores does not achieve what was anticipated.
AB - A novel microporous polyurethane blood conduit developed at the University of Texas at Arlington was implanted as an infra-renal substitute in dogs. The prosthesis was fabricated by precipitating a solution of the polymer with dry nitrogen onto a rotating mandrel. The grafts were sterilized either by gamma radiation (series I) or ethylene oxide (series II); they were implanted for the following prescheduled periods: 4, 24, 48 hours, and J week (short-term) and 2, 4 weeks, 3 and 6 months (medium-term). The thrombohematological characteristics of each animal were evaluated prior to implantation and confirmed that the index of blood coagulability was normal. In the short-term group, five out of eight grafts were patent and three were partially occluded; four grafts in the medium-term group were patent; one was partially occluded; and three were thrombosed at retrieval. One week after implantation, the prostheses were surrounded by an external capsule, which was present mainly at the two anastomoses. The external capsule covered the entire graft at 3 months. No kinking of the grafts was observed and the presence of a mild yellow stain related to bilirubin uptake was detected at 2 weeks, 1, 3, and 6 months. Histological studies have revealed the formation of a thin internal capsule at both anastomoses, 2 weeks postimplantation, which was not anchored to the graft wall. In the medium-term group, the thrombosed grafts failed to develop an internal capsule, whereas the patent graft exhibited a thick internal capsule made of neocollagenous tissue over the entire graft. This new microporous polyurethane prosthesis did not perform satisfactorily as an infra-renal substitute in dogs and its in vivo stability requires further assessment. Thus, the concept of a polyurethane with closed pores does not achieve what was anticipated.
KW - Arterial bypass
KW - Arterial graft
KW - Implantation
KW - Keywords Blood conduit
KW - Polyurethane grafts
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U2 - 10.3109/08941939309141617
DO - 10.3109/08941939309141617
M3 - Article
C2 - 8398999
AN - SCOPUS:0027279796
SN - 0894-1939
VL - 6
SP - 273
EP - 288
JO - Journal of Investigative Surgery
JF - Journal of Investigative Surgery
IS - 3
ER -