TY - JOUR
T1 - A novel leptin receptor isoform in rat
AU - Wang, May-Yun
AU - Zhou, Yan Ting
AU - Newgard, Christopher B.
AU - Unger, Roger H
N1 - Funding Information:
AcknowledgemenTths:e ses tudiesw ere supportedb y an NIH/JDF DiabetesIn terdisciplinarRye searchP rogram( to R.U. and C.B.N.), NationaIln stituteos f HealthG rantD K 02700a, ndV eteranAs dmin-istrationR esearchS upporgt rant5 49-800(0to R.U.). The authorsa re gratefutl o Dr. KazunorKi oyamafo r assistancwei tht issued issection and GuoxunC henfor provisiono f someR NA samples.
PY - 1996/8/26
Y1 - 1996/8/26
N2 - Five mouse and human leptin receptors (Ob-R) have recently been identified, a long isoform (Ob-Rb), preferentially expressed in hypothalamus, and 4 short isoforms, Ob-Ra, Ob-Rc, Ob-Rd, and Oh-Re. We have identified a new short isoform in the rat, r-OB-Rf, with 6 C-terminal amino acids and a 3' untranslated region without homology to other Ob-R isoforms. Its higher expression in rat liver and spleen compared to brain, stomach, kidney, thymus, heart, lung and hypothalamus, contrasts with Ob-Ra and Ob-Rb homologues and raises possibilities of as yet unidentified roles for members of the growing Ob-R gene family.
AB - Five mouse and human leptin receptors (Ob-R) have recently been identified, a long isoform (Ob-Rb), preferentially expressed in hypothalamus, and 4 short isoforms, Ob-Ra, Ob-Rc, Ob-Rd, and Oh-Re. We have identified a new short isoform in the rat, r-OB-Rf, with 6 C-terminal amino acids and a 3' untranslated region without homology to other Ob-R isoforms. Its higher expression in rat liver and spleen compared to brain, stomach, kidney, thymus, heart, lung and hypothalamus, contrasts with Ob-Ra and Ob-Rb homologues and raises possibilities of as yet unidentified roles for members of the growing Ob-R gene family.
KW - Leptin receptor isoform
KW - Ob-R gene
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U2 - 10.1016/0014-5793(96)00790-9
DO - 10.1016/0014-5793(96)00790-9
M3 - Article
C2 - 8772180
AN - SCOPUS:0030603159
SN - 0014-5793
VL - 392
SP - 87
EP - 90
JO - FEBS Letters
JF - FEBS Letters
IS - 2
ER -