TY - JOUR

T1 - A normative theory for causal inference and bayes factor computation in neural circuits

AU - Zhang, Wen Hao

AU - Wu, Si

AU - Doiron, Brent

AU - Lee, Tai Sing

N1 - Funding Information:
This work is supported by National Science Foundation (1816568), Intelligence Advanced Research Projects Activity (D16PC00007), the National Institutes of Health (Grants 1U19NS107613-01 and R01EB026953), the Vannevar Bush Faculty (Fellowship N00014-18-1-2002), and the Simons Foundation Collaboration on the Global Brain. We also thank Rob Kass and Xaq Pitkow for their useful suggestions.
Publisher Copyright:
© 2019 Neural information processing systems foundation. All rights reserved.

PY - 2019

Y1 - 2019

N2 - This study provides a normative theory for how Bayesian causal inference can be implemented in neural circuits. In both cognitive processes such as causal reasoning and perceptual inference such as cue integration, the nervous systems need to choose different models representing the underlying causal structures when making inferences on external stimuli. In multisensory processing, for example, the nervous system has to choose whether to integrate or segregate inputs from different sensory modalities to infer the sensory stimuli, based on whether the inputs are from the same or different sources. Making this choice is a model selection problem requiring the computation of Bayes factor, the ratio of likelihoods between the integration and the segregation models. In this paper, we consider the causal inference in multisensory processing and propose a novel generative model based on neural population code that takes into account both stimulus feature and stimulus reliability in the inference. In the case of circular variables such as heading direction, our normative theory yields an analytical solution for computing the Bayes factor, with a clear geometric interpretation, which can be implemented by simple additive mechanisms with neural population code. Numerical simulation shows that the tunings of the neurons computing Bayes factor are consistent with the "opposite neurons" discovered in dorsal medial superior temporal (MSTd) and the ventral intraparietal (VIP) areas for visual-vestibular processing. This study illuminates a potential neural mechanism for causal inference in the brain.

AB - This study provides a normative theory for how Bayesian causal inference can be implemented in neural circuits. In both cognitive processes such as causal reasoning and perceptual inference such as cue integration, the nervous systems need to choose different models representing the underlying causal structures when making inferences on external stimuli. In multisensory processing, for example, the nervous system has to choose whether to integrate or segregate inputs from different sensory modalities to infer the sensory stimuli, based on whether the inputs are from the same or different sources. Making this choice is a model selection problem requiring the computation of Bayes factor, the ratio of likelihoods between the integration and the segregation models. In this paper, we consider the causal inference in multisensory processing and propose a novel generative model based on neural population code that takes into account both stimulus feature and stimulus reliability in the inference. In the case of circular variables such as heading direction, our normative theory yields an analytical solution for computing the Bayes factor, with a clear geometric interpretation, which can be implemented by simple additive mechanisms with neural population code. Numerical simulation shows that the tunings of the neurons computing Bayes factor are consistent with the "opposite neurons" discovered in dorsal medial superior temporal (MSTd) and the ventral intraparietal (VIP) areas for visual-vestibular processing. This study illuminates a potential neural mechanism for causal inference in the brain.

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M3 - Conference article

AN - SCOPUS:85090169978

SN - 1049-5258

VL - 32

JO - Advances in Neural Information Processing Systems

JF - Advances in Neural Information Processing Systems

T2 - 33rd Annual Conference on Neural Information Processing Systems, NeurIPS 2019

Y2 - 8 December 2019 through 14 December 2019

ER -