A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B

Amos B. Smith; László Kürti; Akin H. Davulcu

doi:10.1021/ol0606536

A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B

Amos B. Smith, László Kürti, Akin H. Davulcu

Biochemistry

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Construction of the highly strained CDEF parent tetracycle, a structural motif found only in the potent ectoparasiticidal agents (+)-nodulisporic acids A and B and related congeners, has been achieved via a new modular indole synthesis, exploiting a sequential Stille cross-coupling/Buchwald-Hartwig union/cyclization tactic. The new indole synthesis holds the promise of rapid assembly of diverse, highly substituted indoles possessing uncommon substitution patterns.

Original language	English (US)
Pages (from-to)	2167-2170
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	10
DOIs	https://doi.org/10.1021/ol0606536
State	Published - May 11 2006

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0606536

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A new modular indole synthesis. Construction of the highly strained CDEF parent tetracycle of nodulisporic acids A and B

Abstract

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