Construction of the highly strained CDEF parent tetracycle, a structural motif found only in the potent ectoparasiticidal agents (+)-nodulisporic acids A and B and related congeners, has been achieved via a new modular indole synthesis, exploiting a sequential Stille cross-coupling/Buchwald-Hartwig union/cyclization tactic. The new indole synthesis holds the promise of rapid assembly of diverse, highly substituted indoles possessing uncommon substitution patterns.
|Original language||English (US)|
|Number of pages||4|
|State||Published - May 11 2006|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry