A new method for radiochemical separation of arsenic from irradiated germanium oxide

M. Jennewein; S. M. Qaim; A. Hermanne; M. Jahn; E. Tsyganov; N. Slavine; S. Seliounine; P. A. Antich; P. V. Kulkarni; P. E. Thorpe; R. P. Mason; F. Rösch

doi:10.1016/j.apradiso.2005.04.005

A new method for radiochemical separation of arsenic from irradiated germanium oxide

M. Jennewein, S. M. Qaim, A. Hermanne, M. Jahn, E. Tsyganov, N. Slavine, S. Seliounine, P. A. Antich, P. V. Kulkarni, P. E. Thorpe, R. P. Mason, F. Rösch

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Radioarsenic labelled radiopharmaceuticals could be a valuable asset to Positron Emission Tomography (PET). In particular, the long half-lives of ⁷²As (T_1/2=26 h) and ⁷⁴As (T_1/2=17.8 d) allow to investigate slow physiological or metabolical processes, like the enrichment and distribution of antibodies in tumor tissue. This work describes the direct production of no-carrier-added (nca) arsenic isotopes*As, with*=71, 72, 73, 74 or 77, the reaction to [*As]AsI₃ and its radiochemical separation from the irradiated solid germanium oxide via polystyrene-based solid-phase extraction. The germanium oxide target, irradiated at a cyclotron or a nuclear reactor, is dissolved in concentrated HF and Ge is separated almost quantitatively (99.97%) as [GeF₆]^2-. [*As]AsI₃ is formed by addition of potassium iodide. The radiochemical separation yield for arsenic is >90%. [*As]AsI ₃ is a versatile radioarsenic labelling synthon.

Original language	English (US)
Pages (from-to)	343-351
Number of pages	9
Journal	Applied Radiation and Isotopes
Volume	63
Issue number	3
DOIs	https://doi.org/10.1016/j.apradiso.2005.04.005
State	Published - Sep 2005

Keywords

As-71
As-72
As-73
As-74
As-77
Radiochemical separation
Solid-phase extraction

ASJC Scopus subject areas

Radiation

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10.1016/j.apradiso.2005.04.005

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@article{6f436ffa1d974bf1961278176dc27330,

title = "A new method for radiochemical separation of arsenic from irradiated germanium oxide",

abstract = "Radioarsenic labelled radiopharmaceuticals could be a valuable asset to Positron Emission Tomography (PET). In particular, the long half-lives of 72As (T1/2=26 h) and 74As (T1/2=17.8 d) allow to investigate slow physiological or metabolical processes, like the enrichment and distribution of antibodies in tumor tissue. This work describes the direct production of no-carrier-added (nca) arsenic isotopes*As, with*=71, 72, 73, 74 or 77, the reaction to [*As]AsI3 and its radiochemical separation from the irradiated solid germanium oxide via polystyrene-based solid-phase extraction. The germanium oxide target, irradiated at a cyclotron or a nuclear reactor, is dissolved in concentrated HF and Ge is separated almost quantitatively (99.97%) as [GeF6]2-. [*As]AsI3 is formed by addition of potassium iodide. The radiochemical separation yield for arsenic is >90%. [*As]AsI 3 is a versatile radioarsenic labelling synthon.",

keywords = "As-71, As-72, As-73, As-74, As-77, Radiochemical separation, Solid-phase extraction",

author = "M. Jennewein and Qaim, {S. M.} and A. Hermanne and M. Jahn and E. Tsyganov and N. Slavine and S. Seliounine and Antich, {P. A.} and Kulkarni, {P. V.} and Thorpe, {P. E.} and Mason, {R. P.} and F. R{\"o}sch",

note = "Funding Information: Financial support was provided by the Deutsche Forschungsgemeinschaft (DFG-Grant Ro 985/9 and 985/17), an NCI P2O pre-ICMIC (CA086334), the NMFZ of the University of Mainz, and by the Boehringer Ingelheim Fonds for Basic Medicinal Research, represented by Dr. H. Fr{\"o}hlich.",

year = "2005",

month = sep,

doi = "10.1016/j.apradiso.2005.04.005",

language = "English (US)",

volume = "63",

pages = "343--351",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Limited",

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T1 - A new method for radiochemical separation of arsenic from irradiated germanium oxide

AU - Jennewein, M.

AU - Qaim, S. M.

AU - Hermanne, A.

AU - Jahn, M.

AU - Tsyganov, E.

AU - Slavine, N.

AU - Seliounine, S.

AU - Antich, P. A.

AU - Kulkarni, P. V.

AU - Thorpe, P. E.

AU - Mason, R. P.

AU - Rösch, F.

N1 - Funding Information: Financial support was provided by the Deutsche Forschungsgemeinschaft (DFG-Grant Ro 985/9 and 985/17), an NCI P2O pre-ICMIC (CA086334), the NMFZ of the University of Mainz, and by the Boehringer Ingelheim Fonds for Basic Medicinal Research, represented by Dr. H. Fröhlich.

PY - 2005/9

Y1 - 2005/9

N2 - Radioarsenic labelled radiopharmaceuticals could be a valuable asset to Positron Emission Tomography (PET). In particular, the long half-lives of 72As (T1/2=26 h) and 74As (T1/2=17.8 d) allow to investigate slow physiological or metabolical processes, like the enrichment and distribution of antibodies in tumor tissue. This work describes the direct production of no-carrier-added (nca) arsenic isotopes*As, with*=71, 72, 73, 74 or 77, the reaction to [*As]AsI3 and its radiochemical separation from the irradiated solid germanium oxide via polystyrene-based solid-phase extraction. The germanium oxide target, irradiated at a cyclotron or a nuclear reactor, is dissolved in concentrated HF and Ge is separated almost quantitatively (99.97%) as [GeF6]2-. [*As]AsI3 is formed by addition of potassium iodide. The radiochemical separation yield for arsenic is >90%. [*As]AsI 3 is a versatile radioarsenic labelling synthon.

AB - Radioarsenic labelled radiopharmaceuticals could be a valuable asset to Positron Emission Tomography (PET). In particular, the long half-lives of 72As (T1/2=26 h) and 74As (T1/2=17.8 d) allow to investigate slow physiological or metabolical processes, like the enrichment and distribution of antibodies in tumor tissue. This work describes the direct production of no-carrier-added (nca) arsenic isotopes*As, with*=71, 72, 73, 74 or 77, the reaction to [*As]AsI3 and its radiochemical separation from the irradiated solid germanium oxide via polystyrene-based solid-phase extraction. The germanium oxide target, irradiated at a cyclotron or a nuclear reactor, is dissolved in concentrated HF and Ge is separated almost quantitatively (99.97%) as [GeF6]2-. [*As]AsI3 is formed by addition of potassium iodide. The radiochemical separation yield for arsenic is >90%. [*As]AsI 3 is a versatile radioarsenic labelling synthon.

KW - As-71

KW - As-72

KW - As-73

KW - As-74

KW - As-77

KW - Radiochemical separation

KW - Solid-phase extraction

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ER -

A new method for radiochemical separation of arsenic from irradiated germanium oxide

Abstract

Keywords

ASJC Scopus subject areas

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