A new chapter: Hematopoietic stem cells are direct players in immunity

Junke Zheng, Chun Song, Chengcheng Zhang

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Several lines of evidence support the hypothesis that hematopoietic stem cells (HSCs) directly interact with the immune system and have potential for immune privilege. Although the microenvironment or niche provides protection for HSCs from immune attack, HSCs are also capable of interacting with the immune system as signal "providers" and signal "receivers". On the one hand, HSCs display surface immune inhibitory molecules to evade the attack from the innate and adaptive immune systems; on the other hand, HSCs are capable of directly sensing the signals from the immune system through their surface receptors. Thus, HSCs are important direct players in the immune system.

Original languageEnglish (US)
Article number33
JournalCell and Bioscience
Issue number1
StatePublished - Oct 6 2011


  • CD274
  • CD47
  • Hematopoietic stem cells
  • Immunity
  • Immunology
  • Infection
  • Inflammation
  • Niche
  • Stem cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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