A new biology of diabetes revealed by leptin

Roger H Unger; Michael G Roth

doi:10.1016/j.cmet.2014.10.011

A new biology of diabetes revealed by leptin

Roger H Unger, Michael G Roth

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

A variety of leptin actions require a re-examination of classic concepts of metabolic diseases. Here we present evidence for two physiologic pathways: a pathway that protects nonadipose tissues from overaccumulation of potentially toxic lipids and unrecognized paracrine interactions between α and β cells revealed by leptin's ability to suppress diabetic hyperglucagonemia. These observations strongly point to new therapeutic possibilities for both type 1 and type 2 diabetes.

Original language	English (US)
Pages (from-to)	15-20
Number of pages	6
Journal	Cell Metabolism
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2014.10.011
State	Published - Jan 6 2015

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2014.10.011

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abstract = "A variety of leptin actions require a re-examination of classic concepts of metabolic diseases. Here we present evidence for two physiologic pathways: a pathway that protects nonadipose tissues from overaccumulation of potentially toxic lipids and unrecognized paracrine interactions between α and β cells revealed by leptin's ability to suppress diabetic hyperglucagonemia. These observations strongly point to new therapeutic possibilities for both type 1 and type 2 diabetes.",

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A new biology of diabetes revealed by leptin

Abstract

ASJC Scopus subject areas

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