A new biology of diabetes revealed by leptin

Roger H Unger, Michael G Roth

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


A variety of leptin actions require a re-examination of classic concepts of metabolic diseases. Here we present evidence for two physiologic pathways: a pathway that protects nonadipose tissues from overaccumulation of potentially toxic lipids and unrecognized paracrine interactions between α and β cells revealed by leptin's ability to suppress diabetic hyperglucagonemia. These observations strongly point to new therapeutic possibilities for both type 1 and type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalCell Metabolism
Issue number1
StatePublished - Jan 6 2015

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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