A model of hemodynamic responses of rat tumors to hyperoxic gas challenge

Mengna Xia; Ralph P. Mason; Hanli Liu

doi:10.1117/12.592291

A model of hemodynamic responses of rat tumors to hyperoxic gas challenge

Mengna Xia, Ralph P. Mason, Hanli Liu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

We measured the changes of oxy-hemoglobin (Δ[HbO ₂]) and deoxy-hemoglobin concentration (Δ[Hb]) in rat breast 13762NF tumors with respect to oxygen or carbogen inhalation using near-infrared spectroscopy (NIRS). The changes in tumor blood flow can be estimated from the NIRS data provided with certain model assumptions. In the theoretical approach, we modified the Windkessel model so as to associate the mathematical model with such physiological parameters of tumor vasculature as total hemoglobin concentration ([HbT]), tumor blood flow (TBF), and tumor metabolic rate of oxygen (TMRO ₂). The computational results show that hyperoxic gas administration to the rat tumors always gave rise to improvement of tumor Δ[HbO ₂], while the same hyperoxic gas intervention could result in different responses in tumor [HbT], TBF, and TMRO ₂. This preliminary study has demonstrated that MRS, a noninvasive tool to monitor tumor oxygenation, may also be used to estimate tumor perfusion and oxygen consumption rate in response to therapeutic interventions, if a suitable mathematical model is provided.

Original language	English (US)
Title of host publication	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Editors	B. Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraca
Pages	301-307
Number of pages	7
Volume	5693
DOIs	https://doi.org/10.1117/12.592291
State	Published - 2005
Event	Optical Tomography and Spectroscopy of Tissue VI - San Jose, CA, United States Duration: Jan 23 2005 → Jan 26 2005

Other

Other	Optical Tomography and Spectroscopy of Tissue VI
Country/Territory	United States
City	San Jose, CA
Period	1/23/05 → 1/26/05

Keywords

Hyperoxic gas
Model
Oxygenation
Tumor

ASJC Scopus subject areas

General Engineering

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10.1117/12.592291

Cite this

A model of hemodynamic responses of rat tumors to hyperoxic gas challenge. / Xia, Mengna; Mason, Ralph P.; Liu, Hanli.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / B. Chance; R.R. Alfano; B.J. Tromberg; M. Tamura; E.M. Sevick-Muraca. Vol. 5693 2005. p. 301-307 61.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Xia, M, Mason, RP & Liu, H 2005, A model of hemodynamic responses of rat tumors to hyperoxic gas challenge. in B Chance, RR Alfano, BJ Tromberg, M Tamura & EM Sevick-Muraca (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 5693, 61, pp. 301-307, Optical Tomography and Spectroscopy of Tissue VI, San Jose, CA, United States, 1/23/05. https://doi.org/10.1117/12.592291

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abstract = "We measured the changes of oxy-hemoglobin (Δ[HbO 2]) and deoxy-hemoglobin concentration (Δ[Hb]) in rat breast 13762NF tumors with respect to oxygen or carbogen inhalation using near-infrared spectroscopy (NIRS). The changes in tumor blood flow can be estimated from the NIRS data provided with certain model assumptions. In the theoretical approach, we modified the Windkessel model so as to associate the mathematical model with such physiological parameters of tumor vasculature as total hemoglobin concentration ([HbT]), tumor blood flow (TBF), and tumor metabolic rate of oxygen (TMRO 2). The computational results show that hyperoxic gas administration to the rat tumors always gave rise to improvement of tumor Δ[HbO 2], while the same hyperoxic gas intervention could result in different responses in tumor [HbT], TBF, and TMRO 2. This preliminary study has demonstrated that MRS, a noninvasive tool to monitor tumor oxygenation, may also be used to estimate tumor perfusion and oxygen consumption rate in response to therapeutic interventions, if a suitable mathematical model is provided. ",

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AB - We measured the changes of oxy-hemoglobin (Δ[HbO 2]) and deoxy-hemoglobin concentration (Δ[Hb]) in rat breast 13762NF tumors with respect to oxygen or carbogen inhalation using near-infrared spectroscopy (NIRS). The changes in tumor blood flow can be estimated from the NIRS data provided with certain model assumptions. In the theoretical approach, we modified the Windkessel model so as to associate the mathematical model with such physiological parameters of tumor vasculature as total hemoglobin concentration ([HbT]), tumor blood flow (TBF), and tumor metabolic rate of oxygen (TMRO 2). The computational results show that hyperoxic gas administration to the rat tumors always gave rise to improvement of tumor Δ[HbO 2], while the same hyperoxic gas intervention could result in different responses in tumor [HbT], TBF, and TMRO 2. This preliminary study has demonstrated that MRS, a noninvasive tool to monitor tumor oxygenation, may also be used to estimate tumor perfusion and oxygen consumption rate in response to therapeutic interventions, if a suitable mathematical model is provided.

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A model of hemodynamic responses of rat tumors to hyperoxic gas challenge

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