A Helping Hand for Cytochrome P450 Enzymes

Research output: Contribution to journalShort surveypeer-review

18 Scopus citations


In this issue of Cell Metabolism, Espenshade and colleagues (Hughes et al., 2007) show that the hemoprotein Dap1/PGRMC1 forms a stable complex with several members of the cytochrome P450 superfamily of enzymes and positively regulates their activities. This action indicates an important role for Dap1/PGRMC1 in P450-catalyzed reactions, some of which are involved in the metabolism of sterols and pharmaceutical compounds.

Original languageEnglish (US)
Pages (from-to)81-83
Number of pages3
JournalCell Metabolism
Issue number2
StatePublished - Feb 7 2007

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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