A Helping Hand for Cytochrome P450 Enzymes

Russell A. DeBose-Boyd

doi:10.1016/j.cmet.2007.01.007

A Helping Hand for Cytochrome P450 Enzymes

Russell A. DeBose-Boyd

Research output: Contribution to journal › Short survey › peer-review

19 Scopus citations

Abstract

In this issue of Cell Metabolism, Espenshade and colleagues (Hughes et al., 2007) show that the hemoprotein Dap1/PGRMC1 forms a stable complex with several members of the cytochrome P450 superfamily of enzymes and positively regulates their activities. This action indicates an important role for Dap1/PGRMC1 in P450-catalyzed reactions, some of which are involved in the metabolism of sterols and pharmaceutical compounds.

Original language	English (US)
Pages (from-to)	81-83
Number of pages	3
Journal	Cell Metabolism
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2007.01.007
State	Published - Feb 7 2007

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2007.01.007

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abstract = "In this issue of Cell Metabolism, Espenshade and colleagues (Hughes et al., 2007) show that the hemoprotein Dap1/PGRMC1 forms a stable complex with several members of the cytochrome P450 superfamily of enzymes and positively regulates their activities. This action indicates an important role for Dap1/PGRMC1 in P450-catalyzed reactions, some of which are involved in the metabolism of sterols and pharmaceutical compounds.",

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AB - In this issue of Cell Metabolism, Espenshade and colleagues (Hughes et al., 2007) show that the hemoprotein Dap1/PGRMC1 forms a stable complex with several members of the cytochrome P450 superfamily of enzymes and positively regulates their activities. This action indicates an important role for Dap1/PGRMC1 in P450-catalyzed reactions, some of which are involved in the metabolism of sterols and pharmaceutical compounds.

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ER -

A Helping Hand for Cytochrome P450 Enzymes

Abstract

ASJC Scopus subject areas

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