TY - JOUR
T1 - A healthy beverage score and risk of chronic kidney disease progression, incident cardiovascular disease, and all-cause mortality in the chronic renal insufficiency cohort
AU - Hu, Emily A.
AU - Anderson, Cheryl A.M.
AU - Crews, Deidra C.
AU - Mills, Katherine T.
AU - He, Jiang
AU - Shou, Haochang
AU - Taliercio, Jonathon J.
AU - Mohanty, Madhumita J.
AU - Bhat, Zeenat
AU - Coresh, Josef
AU - Appel, Lawrence J.
AU - Rebholz, Casey M.
N1 - Publisher Copyright:
© The Author(s) on behalf of the American Society for Nutrition 2020.
PY - 2020
Y1 - 2020
N2 - Background: Beverages are a source of calories and other bioactive constituents but are an understudied aspect of the diet. Different beverages have varying effects on health outcomes. Objectives: We created the Healthy Beverage Score (HBS) to characterize participants’ beverage patterns and examined its association with chronic kidney disease (CKD) progression, incident cardiovascular disease (CVD), and all-cause mortality among individuals with CKD. Methods: We conducted a prospective analysis of 2283 adults aged 21–74 y with a baseline estimated glomerular filtration rate of 20–70 mL · min−1 · 1.73 m−2 from the Chronic Renal Insufficiency Cohort. Diet was assessed using a 124-item FFQ at visit 1 (2003–2008). The HBS, ranging from 7 to 28 possible points, consisted of 7 components, each scored from 1 to 4 based on rank distribution by quartile, except alcohol, which was based on sex-specific cutoffs. Participants were given more points for higher consumption of low-fat milk and of coffee/tea, for moderate alcohol, and for lower consumption of 100% fruit juice, whole-fat milk, artificially sweetened beverages, and sugar-sweetened beverages. CKD progression, incident CVD, and mortality were ascertained through January 2018. We conducted multivariable Cox proportional hazards models. Results: There were 815 cases of CKD progression, 285 cases of incident CVD, and 725 deaths over a maximum of 14 y of follow-up. Compared with participants in the lowest tertile of the HBS, participants in the highest tertile had a 25% lower likelihood of CKD progression (HR: 0.75; 95% CI: 0.63, 0.89; P-trend = 0.001) and a 17% lower likelihood of all-cause mortality (HR: 0.83; 95% CI: 0.69, 1.00; P-trend = 0.04) after adjusting for sociodemographic, clinical, and dietary factors. There was no significant trend for incident CVD. Conclusions: Among individuals with CKD, a healthier beverage pattern was inversely associated with CKD progression and all-cause mortality. Beverage intake may be an important modifiable target in preventing adverse outcomes for individuals with CKD. Curr Dev Nutr 2020;4:nzaa088.
AB - Background: Beverages are a source of calories and other bioactive constituents but are an understudied aspect of the diet. Different beverages have varying effects on health outcomes. Objectives: We created the Healthy Beverage Score (HBS) to characterize participants’ beverage patterns and examined its association with chronic kidney disease (CKD) progression, incident cardiovascular disease (CVD), and all-cause mortality among individuals with CKD. Methods: We conducted a prospective analysis of 2283 adults aged 21–74 y with a baseline estimated glomerular filtration rate of 20–70 mL · min−1 · 1.73 m−2 from the Chronic Renal Insufficiency Cohort. Diet was assessed using a 124-item FFQ at visit 1 (2003–2008). The HBS, ranging from 7 to 28 possible points, consisted of 7 components, each scored from 1 to 4 based on rank distribution by quartile, except alcohol, which was based on sex-specific cutoffs. Participants were given more points for higher consumption of low-fat milk and of coffee/tea, for moderate alcohol, and for lower consumption of 100% fruit juice, whole-fat milk, artificially sweetened beverages, and sugar-sweetened beverages. CKD progression, incident CVD, and mortality were ascertained through January 2018. We conducted multivariable Cox proportional hazards models. Results: There were 815 cases of CKD progression, 285 cases of incident CVD, and 725 deaths over a maximum of 14 y of follow-up. Compared with participants in the lowest tertile of the HBS, participants in the highest tertile had a 25% lower likelihood of CKD progression (HR: 0.75; 95% CI: 0.63, 0.89; P-trend = 0.001) and a 17% lower likelihood of all-cause mortality (HR: 0.83; 95% CI: 0.69, 1.00; P-trend = 0.04) after adjusting for sociodemographic, clinical, and dietary factors. There was no significant trend for incident CVD. Conclusions: Among individuals with CKD, a healthier beverage pattern was inversely associated with CKD progression and all-cause mortality. Beverage intake may be an important modifiable target in preventing adverse outcomes for individuals with CKD. Curr Dev Nutr 2020;4:nzaa088.
KW - All-cause mortality
KW - Cardiovascular disease
KW - Chronic kidney disease progression
KW - CRIC
KW - Healthy beverages
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U2 - 10.1093/CDN/NZAA088
DO - 10.1093/CDN/NZAA088
M3 - Article
AN - SCOPUS:85101241121
SN - 2475-2991
VL - 4
JO - Current Developments in Nutrition
JF - Current Developments in Nutrition
IS - 6
M1 - nzaa088
ER -